{"id":77832,"date":"2018-03-09T23:23:25","date_gmt":"2018-03-09T23:23:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-farmacogenomicas-de-la-predisposicion-a-hemorragia-digestiva-alta-secundaria-al-uso-de-antiinflamatorio-no-esteroideos\/"},"modified":"2018-03-09T23:23:25","modified_gmt":"2018-03-09T23:23:25","slug":"bases-farmacogenomicas-de-la-predisposicion-a-hemorragia-digestiva-alta-secundaria-al-uso-de-antiinflamatorio-no-esteroideos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/bases-farmacogenomicas-de-la-predisposicion-a-hemorragia-digestiva-alta-secundaria-al-uso-de-antiinflamatorio-no-esteroideos\/","title":{"rendered":"Bases farmacogen\u00f3micas de la predisposici\u00f3n a hemorragia digestiva alta secundaria al uso de antiinflamatorio no esteroideos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gerardo Blanco Fern\u00e1ndez <\/strong><\/h2>\n<p>Introducci\u00f3n     la hemorragia digestiva alta (hda) es un efecto adverso frecuente del uso de aines. La mayor\u00eda de estos f\u00e1rmacos se metabolizan en el h\u00edgado a trav\u00e9s del citocromo p450. Las enzimas cyp2c8 y cyp2c9 tienen un papel relevante en el metabolismo de numerosos aines. Estas enzimas pueden sufrir alteraci\u00f3n en la capacidad metab\u00f3lica determinada gen\u00e9ticamente. Las variantes cyp2c8*3, cyp2c9*2 y cyp2c9*3, las m\u00e1s frecuentes en nuestra poblaci\u00f3n, presentan una actividad metab\u00f3lica reducida. Dado que numerosos aines se metabolizan a trav\u00e9s de estas enzimas, y que una actividad enzim\u00e1tica reducida condiciona niveles plasm\u00e1ticos m\u00e1s elevados de f\u00e1rmaco, la hip\u00f3tesis de trabajo es que la posesi\u00f3n de las variantes al\u00e9licas cyp2c8*3, cyp2c9*2 y\/o cyp2c9*3 incrementa el riesgo de desarrollar hda relacionada con el uso de aines.  pacientes, material y m\u00e9todos     han participado un grupo de 134 pacientes con hda tras el uso de aines, otro grupo de 177 pacientes tratados de forma cr\u00f3nica con aines sin antecedentes personales ni familiares de hda y un grupo control de 355 individuos sin patolog\u00eda ni h\u00e1bitos t\u00f3xicos conocidos. En todos los individuos se investiga la presencia de las variantes al\u00e9licas m\u00e1s frecuentes decyp2c8 y cyp2c9.  resultados     hemos encontrado un porcentaje significativamente mayor de individuos portadores de las variantes cyp2c8*3, cyp2c9*2 y en menor medida cyp2c9*3 en el grupo de hda. En el caso de pacientes que consumen f\u00e1rmacos con metabolismo principal a trav\u00e9s de cyp2c8 y cyp2c9 los odds ratio encontrados son: para cyp2c8*3 or=2,71(1,23-5,95), chi cuadrado 6,186(p=0,013); para cyp2c9*2 or=2,31(1,07-5), chi cuadrado 4,494(p=0,034) y e caso de asociaci\u00f3n cyp2c8*3+cyp2c9*2, or=2,80(1,21-6,47), chi cuadrado 5,823(p=0,016). Sin embargo para los pacientes que consumen f\u00e1rmacos con metabolismo parcial a trav\u00e9s de estas enzimas los odds ratio son: para cyp2c8*3 or=1,3(0,65-2,6), chi cuadrado 0,525(p=0,469);<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases farmacogen\u00f3micas de la predisposici\u00f3n a hemorragia digestiva alta secundaria al uso de antiinflamatorio no esteroideos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases farmacogen\u00f3micas de la predisposici\u00f3n a hemorragia digestiva alta secundaria al uso de antiinflamatorio no esteroideos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gerardo Blanco Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Carmen Mart\u00ednez Oliva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Mi\u00f1ano s\u00e1nchez <\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero quesada (vocal)<\/li>\n<li>Antonio Fern\u00e1ndez alonso (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gerardo Blanco Fern\u00e1ndez Introducci\u00f3n la hemorragia digestiva alta (hda) es un efecto adverso frecuente del uso de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[949,957,491,11771,2820],"tags":[10806,167470,55490,6504,94579],"class_list":["post-77832","post","type-post","status-publish","format-standard","hentry","category-extremadura","category-farmacologia","category-gastroenterologia","category-genetica-clinica","category-genetica-humana","tag-antonio-fernandez-alonso","tag-gerardo-blanco-fernandez","tag-javier-minano-sanchez","tag-jose-maria-ladero-quesada","tag-ma-carmen-Martinez-oliva"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=77832"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/77832\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=77832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=77832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=77832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}