{"id":77874,"date":"2018-03-09T23:23:25","date_gmt":"2018-03-09T23:23:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-efectos-producidos-por-la-administracion-cronica-de-manganeso-implicacion-de-la-ingesta-de-hierro\/"},"modified":"2018-03-09T23:23:25","modified_gmt":"2018-03-09T23:23:25","slug":"estudio-de-los-efectos-producidos-por-la-administracion-cronica-de-manganeso-implicacion-de-la-ingesta-de-hierro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-los-efectos-producidos-por-la-administracion-cronica-de-manganeso-implicacion-de-la-ingesta-de-hierro\/","title":{"rendered":"Estudio de los efectos producidos por la administraci\u00f3n cr\u00f3nica de manganeso: implicaci\u00f3n de la ingesta de hierro"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez Hidalgo Mary Cruz <\/strong><\/h2>\n<p>En la tesis titulada \u00bb estudio de los efectos producidos por la administraci\u00f3n cr\u00f3nica de manganeso: implicaci\u00f3n de la ingesta de hierro \u00bb se ha evaluado el efecto t\u00f3xico que el manganeso, considerado un oligoelemento, puede llevar a cabo en el snc, sobre todo en el sistema dopamin\u00e9rgico nigro-estriado, as\u00ed como en diversos \u00f3rganos perif\u00e9ricos.  dicha administraci\u00f3n cr\u00f3nica se realiz\u00f3 en ratas wistar empleando mncl2 por v\u00eda intraperitoneal. Asimismo, tambi\u00e9n se abord\u00f3 el papel que el manganeso y el hierro podr\u00edan tener en el proceso de neurodegeneraci\u00f3n y afectaci\u00f3n de \u00f3rganos perif\u00e9ricos, para lo que se dise\u00f1\u00f3 un experimento en el que se emplearon dietas sint\u00e9ticas con dosis normal de hierro y carencia del mismo.  as\u00ed pues, se estudi\u00f3 la respuesta glial, indicativa de da\u00f1os a nivel cerebral, se valoraron par\u00e1metros de estr\u00e9s oxidativo y se efectuaron diversas tinciones inmunocitoqu\u00edmicas as\u00ed como hibridaci\u00f3n in situ.  de esta forma, nuestro estudio refleja que la toxicidad del manganeso en el snc se basa en el aumento del estr\u00e9s oxidativo produci\u00e9ndose un mayor efecto del manganeso en el sistema dopamin\u00e9rgico nigro-estriado, si bien no act\u00faa de forma selectiva puesto que todas las estructuras cerebrales estudiadas muestran estr\u00e9s oxidativo.  asimismo, tambi\u00e9n produce un aumento de estr\u00e9s oxidativo en \u00f3rganos sist\u00e9micos, entre los que destaca el higado, pudi\u00e9ndose especular con la posibilidad de la disfunci\u00f3n de este \u00f3rgano y el desarrollo de encefalopatia hep\u00e1tica.  tambi\u00e9n es importante destacar que la deficiencia de hierro y elevados niveles de manganeso en el snc presentan un efecto t\u00f3xico sin\u00e9rgico desencadenando una gran respuesta glial as\u00ed como afectaci\u00f3n vascular y par\u00e9nquima cerebral que presupone fen\u00f3menos de necrosis y apoptosis concluyendo con la muerte cerebral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los efectos producidos por la administraci\u00f3n cr\u00f3nica de manganeso: implicaci\u00f3n de la ingesta de hierro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los efectos producidos por la administraci\u00f3n cr\u00f3nica de manganeso: implicaci\u00f3n de la ingesta de hierro <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez Hidalgo Mary Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josefina Cano Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Machado de la quintana <\/li>\n<li>Luis Granero mac\u00edas (vocal)<\/li>\n<li>Luis Bravo d\u00edaz (vocal)<\/li>\n<li>martiniano Santiago pav\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez Hidalgo Mary Cruz En la tesis titulada \u00bb estudio de los efectos producidos por la administraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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