{"id":77903,"date":"2018-03-09T23:23:29","date_gmt":"2018-03-09T23:23:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-in-vivo-e-in-vitro-del-tallo-ribosomico-de-saccharomyces-cerevisiae-mediante-tecnicas-biofa%c2%adsicas-y-bioqua%c2%admicas\/"},"modified":"2018-03-09T23:23:29","modified_gmt":"2018-03-09T23:23:29","slug":"estudios-in-vivo-e-in-vitro-del-tallo-ribosomico-de-saccharomyces-cerevisiae-mediante-tecnicas-biofa%c2%adsicas-y-bioqua%c2%admicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudios-in-vivo-e-in-vitro-del-tallo-ribosomico-de-saccharomyces-cerevisiae-mediante-tecnicas-biofa%c2%adsicas-y-bioqua%c2%admicas\/","title":{"rendered":"Estudios in vivo e in vitro del tallo ribos\u00f3mico de saccharomyces cerevisiae mediante t\u00e9cnicas biof\u00edsicas y bioqu\u00edmicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Garc\u00eda Marcos <\/strong><\/h2>\n<p>El tallo ribos\u00f3mico es una estructura protuberante lateral muy flexible en la subunidad mayor del ribosoma. En procariotas, est\u00e1 compuesta por una prote\u00edna central llamada l10, y otras cuatro prote\u00ednas denominadas \u00e1cidas que se unen en forma de d\u00edmeros l7\/l12. Es s. Cerevisiae la complejidad es mayor, ya que adem\u00e1s de la prote\u00edna central, denominada en este caso p0, hay 4 prote\u00ednas \u00e1cias distintas: p1a, p1b, p2a y p2b. Aunque la mayor\u00eda de datos experimentales apuntan a que estas prote\u00ednas \u00e1cidas se unen en forma de mon\u00f3meros a los ribosomas, y por tanto estos siguen una distribuci\u00f3n homog\u00e9nea en la c\u00e9lula, con tallos compuestos por una prote\u00edna \u00e1cida de cada tipo. Sin embargo, ciertos datos de entrecruzamiento qu\u00edmico, la comparaci\u00f3n con procariotas, y la capacidad de p2b en soluci\u00f3n de formar homod\u00edmeros, hacen pensar que tambi\u00e9n pudiera darse un modelo heterog\u00e9neo de composici\u00f3n de los ribosomas, con distintas combinaciones de homod\u00edmeros de las prote\u00ednas \u00e1cidas. Todo esto tiene una importancia no s\u00f3lo estructural, sino tambi\u00e9n funcional, ya que en funci\u00f3n de las prote\u00ednas \u00e1cidas unidas al ribosoma, se ha comprobado que var\u00eda el patr\u00f3n de prote\u00ednas que la c\u00e9lula expresa.  con el objetivo general de dilucidar la presencia o ausencia de homod\u00edmeros de prote\u00ednas \u00e1cidas en el ribosoma, y discriminar entre la existencia del modelo homog\u00e9neo o heterog\u00e9neo de composici\u00f3n del tallo ribos\u00f3mico, se plantearon una serie de objetivos y t\u00e9cnicas espec\u00edficas.  en primer lugar, se sustituyeron  residuos de algunas prote\u00ednas prote\u00ednas \u00e1cidas por ciste\u00ednas y se realizaron experimentos de entrecruzamiento qu\u00edmico. los resultados obtenidos son compatibles con un modelo homog\u00e9neo de composici\u00f3n del tallo ribos\u00f3mico, y tambi\u00e9n muestran una interacci\u00f3n directa entre p2a y p1b. Se comprueba adem\u00e1s, que la aparici\u00f3n de homod\u00edmeros de p2a (con un residuo mutado a ciste\u00edna) en cepas en las que se ha el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios in vivo e in vitro del tallo ribos\u00f3mico de saccharomyces cerevisiae mediante t\u00e9cnicas biof\u00edsicas y bioqu\u00edmicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios in vivo e in vitro del tallo ribos\u00f3mico de saccharomyces cerevisiae mediante t\u00e9cnicas biof\u00edsicas y bioqu\u00edmicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Garc\u00eda Marcos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Pedro Garc\u00eda Ballesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alonso Rodriguez navarro <\/li>\n<li> Revuelta doval Jos\u00e9 Luis (vocal)<\/li>\n<li>ricardo Amils pibernat (vocal)<\/li>\n<li>pilar Lillo villalobos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Garc\u00eda Marcos El tallo ribos\u00f3mico es una estructura protuberante lateral muy flexible en la subunidad mayor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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