{"id":7797,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/prevencion-del-dano-renal-postisquemico-mediante-un-antagonista-del-factor-de-activacion-plaquetaria-web-2086-y-un-quelante-del-hierro-desferroxamina-modelo-experimental-en-el-conejo\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"prevencion-del-dano-renal-postisquemico-mediante-un-antagonista-del-factor-de-activacion-plaquetaria-web-2086-y-un-quelante-del-hierro-desferroxamina-modelo-experimental-en-el-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/prevencion-del-dano-renal-postisquemico-mediante-un-antagonista-del-factor-de-activacion-plaquetaria-web-2086-y-un-quelante-del-hierro-desferroxamina-modelo-experimental-en-el-conejo\/","title":{"rendered":"Prevencion del da\u00f1o renal postisquemico mediante un antagonista del factor de activacion plaquetaria web-2086 y un quelante del hierro (desferroxamina). modelo experimental en el conejo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Alonso Jos\u00e9 Antonio <\/strong><\/h2>\n<p>Introduccion: a pesar de los numerosos avances en cirugia vascular durante las ultimas decadas, la incidencia y mortalidad del fallo renal agudo (fra) postoperatorio no ha disminuido significativamente. Recientemente ha sido demostrado que, despues de un fra postisquemico, el ri\u00f1on aumenta la produccion de factor de activacion plaquetaria (paf). Por otro lado, la produccion de radicales libres de oxigeno supone la iniciacion del da\u00f1o isquemico tisular y, para su sintesis, es necesaria la presencia de hierro.  hipotesis de trabajo: por tanto, cabe pensar que la administracion, antes de inducir una isquemia renal normotenica de un antagonista selectivo del paf como el web-2086 o de un quelante del hierro como la desferroxamina, pueden ejercer un efecto protector renal frente al da\u00f1o isquemico.  objetivo: el objetivo de este estudio ha sido evaluar el efecto protector en la isquemia renal normotermica de dos farmacos: un antagonista especifico del paf (web-2086) y un quelante del hierro (desferroxamina).  material y metodos: treinta conejos neo-zelandeses albinos fueron estudiados en jaulas metabolicas desde 1 dia antes hasta 24 horas despues de un periodo de isquemia renal de 60 minutos inducido mediante el clampaje de las arterias renales. Los animales fueron divididos en un grupo control (grupo a, n=10), un grupo tratado con web-2086 (grupo b, n=10) y un grupo tratado con desferroxamina (grupo c, n=10). Los grupos tratados no difirieron en el protocolo respecto al grupo control excepto en la administracion de una solucion al 0.3% de web-2086 a la dosis de 1mg\/kg peso de desferroxamina en el grupo c. Fueron analizados los valores basal y postisquemico de la funcion reanl (diuresis, creatinina plasmatica, aclaramiento de creatinina, cociente osmolalidad orina\/plasma, fraccion de excrecion de sodio y n-acetil-b-d-glucosaminidasa). Se determino ademas el flujo microcirculatorio cortical renal mediante el registro fotopletismogr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prevencion del da\u00f1o renal postisquemico mediante un antagonista del factor de activacion plaquetaria web-2086 y un quelante del hierro (desferroxamina). modelo experimental en el conejo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prevencion del da\u00f1o renal postisquemico mediante un antagonista del factor de activacion plaquetaria web-2086 y un quelante del hierro (desferroxamina). modelo experimental en el conejo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Alonso Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Vaquero Puerta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Guillermo Ramos Seisdedos <\/li>\n<li>Jes\u00fas Bustamante Bustamante (vocal)<\/li>\n<li>Juan Lopez Arranz (vocal)<\/li>\n<li>Francisco Rivera Hueto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Alonso Jos\u00e9 Antonio Introduccion: a pesar de los numerosos avances en cirugia vascular durante las ultimas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,1550,12451],"tags":[9258,27768,10967,12541,12644,9653],"class_list":["post-7797","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-cirugia-vascular","category-valladolid","tag-carlos-vaquero-puerta","tag-fernandez-alonso-jose-antonio","tag-francisco-rivera-hueto","tag-guillermo-ramos-seisdedos","tag-jesus-bustamante-bustamante","tag-juan-lopez-arranz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7797"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7797\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}