{"id":78039,"date":"2018-03-09T23:23:38","date_gmt":"2018-03-09T23:23:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/migracion-terapeutica-de-la-quimiotaxis-de-celulas-t-cd4-y-cd8-mediante-el-uso-de-fty720\/"},"modified":"2018-03-09T23:23:38","modified_gmt":"2018-03-09T23:23:38","slug":"migracion-terapeutica-de-la-quimiotaxis-de-celulas-t-cd4-y-cd8-mediante-el-uso-de-fty720","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/migracion-terapeutica-de-la-quimiotaxis-de-celulas-t-cd4-y-cd8-mediante-el-uso-de-fty720\/","title":{"rendered":"Migraci\u00f3n terap\u00e9utica de la quimiotaxis de c\u00e9lulas t cd4 y cd8 mediante el uso de fty720"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pe\u00f1uelas Rivas Claudia Giovanna <\/strong><\/h2>\n<p>Se evalu\u00f3 el efecto del fty720 en ratones con un repertorio limitado de linfocitos (timectomizados) y con deplecci\u00f3n de c\u00e9lulas t cd4 y t cd 8 para observar si el f\u00e1rmaco alteraba la activaci\u00f3n de los linfocitos en modelos de transplanten alog\u00e9nico de piel a trav\u00e9s de las barreras de histocompatibilidad clas 1,clase\u00bb\u00bb y total. Adem\u00e1s se analiz\u00f3 el efecto del fty720 en la respuesta hemost\u00e1tica celular en ratones nude balbc o en ratones c57 bl6 que fueron irradiados a dosis mieloablativas. Tambi\u00e9n se evalu\u00f3 el efecto de la droga durante la gestaci\u00f3n y la lactaci\u00f3n epara el desarrollo t\u00edmico en ratones neonatos de 15 dias de nacidos. En los diferentes modelos de transplantes se pudo observar que los ratones en los que se administr\u00f3 el fty720 retrasaron los rechazos de piel. Adem\u00e1s se observ\u00f3 que los animales aut\u00edmicos retrasaron significativamente m\u00e1s el rechazo que los animales timectomizados. En la prueba de ctl los ratones con fty720 fueron capaces de desarrollar una respuesta citot\u00f3xica normal en comparaci\u00f3n de los grupos de animales que no recibieron tratamiento. En la prueba de mlr la respuesta celular proliferativa, en los animales tratados con fty720, no se vi\u00f3 disminuida. \u00fanicamente se observ\u00f3 que en los ratones timectomizados la respuesta fue menor que en los eut\u00edmicos.  no se observ\u00f3 respuesta inmune humoral en los modelos de transplantes clase i y clase \/l. Para el modelo histoincompatible total sed observ\u00f3 una respuesta humoral antidonante especifica para igg2a e igg2b donde estuvo significativamente disminuida en el grupo de ratones eut\u00edmicos tratados con fty720 en comparaci\u00f3n de los dem\u00e1s grupos. En cuanto a la producc\u00f3n de gifn, el tratamiento prolongado con fty720 no la alter\u00f3 en ninguno de los modelos. La proliferaci\u00f3n homeost\u00e1tica celular no se vi\u00f3 alterada por la presen cia de fty720 en ninguno de los modelos experimetales. Ei tratamiento con fty720 en ratonas gestantes o lactantes, no<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Migraci\u00f3n terap\u00e9utica de la quimiotaxis de c\u00e9lulas t cd4 y cd8 mediante el uso de fty720<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Migraci\u00f3n terap\u00e9utica de la quimiotaxis de c\u00e9lulas t cd4 y cd8 mediante el uso de fty720 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pe\u00f1uelas Rivas Claudia Giovanna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mu\u00f1oz Luna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Bernabe salazar <\/li>\n<li>Juan  anselmo Perea remujo (vocal)<\/li>\n<li>librado Carrasco otero (vocal)<\/li>\n<li>pablo Ram\u00edrez romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pe\u00f1uelas Rivas Claudia Giovanna Se evalu\u00f3 el efecto del fty720 en ratones con un repertorio limitado de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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