{"id":78110,"date":"2018-03-09T23:23:41","date_gmt":"2018-03-09T23:23:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-dels-desequilibris-cromosomics-en-tumors-solids-epitelials-esporadics-i-familiars\/"},"modified":"2018-03-09T23:23:41","modified_gmt":"2018-03-09T23:23:41","slug":"estudi-dels-desequilibris-cromosomics-en-tumors-solids-epitelials-esporadics-i-familiars","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudi-dels-desequilibris-cromosomics-en-tumors-solids-epitelials-esporadics-i-familiars\/","title":{"rendered":"Estudi dels desequilibris cromosomics en tumors solids epitelials esporadics i familiars"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ester Prat Pedrola <\/strong><\/h2>\n<p>El c\u00e1ncer es un conjunto de m\u00ed\u00a0s de 100 enfermedades que se caracterizan por la acumulaci\u00f3n de multiples alteraciones gen\u00e9ticas. De la diversas enfermedades que se incluyen en esta terminolog\u00eda, nosotros nos hemos centrado en el estudio de tres tipos de tumores s\u00f3lidos epiteliales: tumores espor\u00e1dicos de vejiga, tumores hereditarios o familiares de c\u00e1ncer colorectal y de c\u00e1ncer de ri\u00f1\u00f3n.  para realizar los estudios que componen esta tesis doctoral, la t\u00e9cnica que se ha utilizado de manera m\u00e1s habitual ha sido de hibridaci\u00f3n gen\u00f3mica comparada (cgh). El an\u00e1lisis global del genoma que permite hacer esta t\u00e9cnica, nos proporciona informaci\u00f3n sobre los desquilibrios, ya sean ganacias o p\u00e9rdidas; que se producen de manera m\u00e1s frequente y por lo tanto que regiones ser\u00edan susceptibles de contener genes supresores de tumores o oncogenes; adem\u00e1s tambi\u00e9n permite llevar a cabo estudios de clonalidad y detectar diferrentes patrones convergentes o divergentes de evoluci\u00f3n cromos\u00f3mica.  en lo referente a los tumores de vejiga, estos son muy heterogeneos tanto morfol\u00f3gicamente como cl\u00ednicamente, es por este motivo que uno de los objetivos que nos planteamos, fue el hecho de aportar nuevos datos sobre desequilibrios gen\u00f3micos de estos tumores. En nuestros estudios observamos que los tumores de c\u00e9lulas transicionales (tcc) de vejiga, el da\u00f1o gen\u00f3mico aumentaba con el estadio y el grado tumoral, siendo los desequilibrios m\u00e1s frequentes, los correspondientes a las p\u00e9rdidas de 9q, 9p, 5q, 8p y las ganancias de 1q, xq, 17q, 8q i 20q. Sin embargo, hay una serie de alteraciones que presentan diferencias significativas entre los diferentes estadios tumorales. Las alteraciones que presentan diferencias significativas entre los estadios pta y pt1 son las p\u00e9rdidas de 5q, 9p, 9q, 10q, 8p, 11q, 18q y las ganancias de 8q, 10p. Mientras que entre tumores pt1 i pt2-t4, las que presentan diferencias significativas son las ganancias de 5p,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi dels desequilibris cromosomics en tumors solids epitelials esporadics i familiars<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi dels desequilibris cromosomics en tumors solids epitelials esporadics i familiars <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ester Prat Pedrola <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Miro Ametller<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Corominas torres <\/li>\n<li>margarita Nadal s\u00e1nchez (vocal)<\/li>\n<li>Antonio Asensio alcaraz (vocal)<\/li>\n<li>gemma Armengol rosell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ester Prat Pedrola El c\u00e1ncer es un conjunto de m\u00ed\u00a0s de 100 enfermedades que se caracterizan por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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