{"id":78142,"date":"2018-03-09T23:23:46","date_gmt":"2018-03-09T23:23:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-pit-1-sobre-la-expresion-de-gh-y-proliferacion-celular-en-glandula-mamaria-humana\/"},"modified":"2018-03-09T23:23:46","modified_gmt":"2018-03-09T23:23:46","slug":"efecto-de-pit-1-sobre-la-expresion-de-gh-y-proliferacion-celular-en-glandula-mamaria-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-de-pit-1-sobre-la-expresion-de-gh-y-proliferacion-celular-en-glandula-mamaria-humana\/","title":{"rendered":"Efecto de pit-1 sobre la expresi\u00f3n de gh y proliferaci\u00f3n celular en gl\u00e1ndula mamaria humana."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gil Puig M. Del Carmen <\/strong><\/h2>\n<p>El c\u00e1ncer de mama es la enfermedad con mayor \u00edndice de mortalidad por neoplasia en las mujeres. Se trata de una enfermedad hormonodependiente, donde las hormonas tanto ov\u00e1ricas como hipofisarias juegan un importante papel no s\u00f3lo en el desarrollo normal de la mama sino tambi\u00e9n en el desarrollo del tumor.Desde los primeros estudios que relacionan el incremento de gh en plasma con el riesgo de padecer c\u00e1ncer de mama, numerosos trabajos han intentado establecer una relaci\u00f3n entre la expresi\u00f3n de gh en la propia gl\u00e1ndula mamaria y el desarrollo del tumor.  en hip\u00f3fisis, a nivel fisiol\u00f3gico, el factor de trascripci\u00f3n hipofisario, pit-1 es necesario para la expresi\u00f3n de los genes que codifican para la hormona de crecimiento, prolactina y la subunidad beta de la tsh. Sin embargo, el papel de pit-1 a nivel extrahipofisario es discutido. Algunos estudios han demostrado que pit-1 incrementa la proliferaci\u00f3n de c\u00e9lulas hipofisarias, sugiriendo que este factor puede estar implicado en la patog\u00e9nesis tumoral hipofisaria.  en este trabajo analizamos la expresi\u00f3n de gh y pit-1 en la linea celular mcf-7 (adenocarcinoma mamario humano) y la regulaci\u00f3n de gh por pit-1. paralelamente, se realiza un estudio sobre la expresi\u00f3n de pit-1 en tejido normal y tumoral mamario. Valoramos tambi\u00e9n el papel de pit-1 sobre la proliferaci\u00f3n celular.  nuestros resultados muestran que tanto gh como pit-1 se expresan en la l\u00ednea celular mcf-7. En estas c\u00e9lulas, pit-1 regula a nivel transcripcionalla expresi\u00f3n de gh. En muestras de tejido humano, existe una mayor expresi\u00f3n de pit-1 en carcinomas ductales infiltrantes que en tejido mamario normal. adem\u00e1s, demostramos que la sobreexpresi\u00f3n de pit-1 en la l\u00ednea celular mcf-7 incrementa significativamente la proliferaci\u00f3n celular.  nuestros resultados sugieren que pit-1, directamente o a trav\u00e9s de otros mediadores (como gh), pueden jugar un importante papel en el desarrollo y\/o progresi\u00f3n del c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de pit-1 sobre la expresi\u00f3n de gh y proliferaci\u00f3n celular en gl\u00e1ndula mamaria humana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de pit-1 sobre la expresi\u00f3n de gh y proliferaci\u00f3n celular en gl\u00e1ndula mamaria humana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gil Puig M. Del Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Roman Perez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Devesa m\u00fagica <\/li>\n<li>federico Mallo ferrer (vocal)<\/li>\n<li>tom\u00e1s Garc\u00eda caballero parada (vocal)<\/li>\n<li>azucena Esparis organo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gil Puig M. Del Carmen El c\u00e1ncer de mama es la enfermedad con mayor \u00edndice de mortalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17,977],"tags":[168065,54291,168064,21164,35230,2892],"class_list":["post-78142","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","category-santiago-de-compostela","tag-azucena-esparis-organo","tag-federico-mallo-ferrer","tag-gil-puig-m-del-carmen","tag-jesus-devesa-mugica","tag-roman-perez-fernandez","tag-tomas-garcia-caballero-parada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78142"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78142\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}