{"id":78147,"date":"2018-03-09T23:23:46","date_gmt":"2018-03-09T23:23:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/melatonina-exogena-y-endogena-en-el-sistema-inmune-efectos-biologicos-y-mecanismos-de-accion\/"},"modified":"2018-03-09T23:23:46","modified_gmt":"2018-03-09T23:23:46","slug":"melatonina-exogena-y-endogena-en-el-sistema-inmune-efectos-biologicos-y-mecanismos-de-accion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inmunologia\/melatonina-exogena-y-endogena-en-el-sistema-inmune-efectos-biologicos-y-mecanismos-de-accion\/","title":{"rendered":"Melatonina ex\u00f3gena y end\u00f3gena en el sistema inmune: efectos biol\u00f3gicos y mecanismos de acci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Carrillo Vico <\/strong><\/h2>\n<p>La melatonina es un compuesto que se describi\u00f3 por primera vez en 1958 como una hormona sintetizada por la gl\u00e1ndula pineal. actualmente, se puede considerar como un compuesto pleiotr\u00f3pico con importantes propiedades cronobi\u00f3ticos, antioxidantes, oncost\u00e1ticas e inmunomodulares. Ejerce sus funciones a trav\u00e9s de diversos mecanismos de acci\u00f3n, entre ellos, por medio de la uni\u00f3n a receptores de membrana y nucleares. En los \u00faltimos a\u00f1os, se ha puesto de manifiesto la presencia de este compuesto en un gran n\u00famero de \u00f3rganos, tejidos y c\u00e9lulas, lo cual ha puesto de manifiesto la posibilidad de fuentes extrapineales de melatonina, contribuyendo a redefinir la l\u00ednea cl\u00e1sica de pensamiento acerca de la melatonina como una hormona exclusivamente pineal.     en funci\u00f3n de estos antecedentes, los objetivos planteados fueron los siguientes:     1,- localizar e identificar sitios de uni\u00f3n para melatonina en c\u00e9lulas de timo y bazo de rat\u00f3n.     2,- detectar la expresi\u00f3n g\u00e9nica de los receptores para melatonina mt1, mt2 y roralfa, as\u00ed como la expresi\u00f3n de las prote\u00ednas mt1 y roralfa1 en timo y bazo de rat\u00f3n.     3,- analizar el efecto de la melatonina a trav\u00e9s de sus receptores de membrana sobre la inhibici\u00f3n de la producci\u00f3n de il-2 inducida por la pge2, en cultivos primarios de pbmcs humanas.     4,- identificar s\u00edntesis activa de melatonina en cultivos primarios de pbmcs humanas.     5,- analizar los efectos y los mecanismos de acci\u00f3n de la melatonina end\u00f3gena sobre el sistema il-2\/il-2r.     las conclusiones a las que llega el estudio tras evaluar los resultados fueron:     1,- existen sitios de uni\u00f3n para melatonina en membrana plasm\u00e1tica y n\u00facleo de c\u00e9lulas de timo y bazo de rat\u00f3n.     2,- los genes que codifican los receptores de melatonina mt1 y roralfa se expresan en timo y bazo de rat\u00f3n, mientras que la expresi\u00f3n de mt2 s\u00f3lo se detecta en timo.     3,- tanto el timo como el bazo de rat\u00f3n presentna las prote\u00ednas m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Melatonina ex\u00f3gena y end\u00f3gena en el sistema inmune: efectos biol\u00f3gicos y mecanismos de acci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Melatonina ex\u00f3gena y end\u00f3gena en el sistema inmune: efectos biol\u00f3gicos y mecanismos de acci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Carrillo Vico <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Guerrero Mont\u00e1vez Juan  Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Delgado jos\u00e9 <\/li>\n<li>dario Acu\u00f1a castroviejo (vocal)<\/li>\n<li>Jes\u00fas \u00e1ngel Fern\u00e1ndez-tresguerres hern\u00e1ndez (vocal)<\/li>\n<li>Juan  ram\u00f3n Calvo guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Carrillo Vico La melatonina es un compuesto que se describi\u00f3 por primera vez en 1958 como 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