{"id":78148,"date":"2018-03-09T23:23:46","date_gmt":"2018-03-09T23:23:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-factores-antiapoptoticos-bcl-xl-y-hsp60-en-la-progresion-y-hormonorresistencia-del-cancer-de-prostata\/"},"modified":"2018-03-09T23:23:46","modified_gmt":"2018-03-09T23:23:46","slug":"papel-de-los-factores-antiapoptoticos-bcl-xl-y-hsp60-en-la-progresion-y-hormonorresistencia-del-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/papel-de-los-factores-antiapoptoticos-bcl-xl-y-hsp60-en-la-progresion-y-hormonorresistencia-del-cancer-de-prostata\/","title":{"rendered":"Papel de los factores antiapopt\u00f3ticos bcl-xl y hsp60 en la progresi\u00f3n y hormonorresistencia del c\u00e1ncer de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Congregado Ruiz Carmen Belen <\/strong><\/h2>\n<p>Las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata sensibles a terapia con bloqueo hormonal androg\u00e9nico se convierten en hormonorresistentes a trav\u00e9s de mecanismos complejos que implican una disregulaci\u00f3n de las v\u00edas de apoptosis.     hemos investigado el papel de las prote\u00ednas de la familia bcl-2 con actividad proapopt\u00f3tica bax y bak, as\u00ed como la antiapopt\u00f3tica bcl-xl, en la progresi\u00f3n a la hormonorresistencia, y el mecanismo mediante el cual la chaperona hsp60 ejerce su papel antiapot\u00f3tico en el c\u00e1ncer de pr\u00f3stata.     hemos utilizado tejidos procedentes de 139 pacientes de c\u00e1ncer de pr\u00f3stata localizado, localmente avanzado y metast\u00e1tico, as\u00ed como la l\u00ednea celular de c\u00e1ncer de pr\u00f3stata hormonorresistente pc3 y la hormonosensible lncap.     la muestras se han analizado mediante las siguientes t\u00e9cnicas:     * expresi\u00f3n de prote\u00edna: estudio inmunohistoqu\u00edmico y western blot.     * interacci\u00f3n entre prote\u00ednas: co-inmunoprecipitaci\u00f3n.     * detecci\u00f3n de apoptosis: estudio inmunohistoqu\u00edmico del epitopo m30, cultivos celulares e inducci\u00f3n de apoptosis con ultravioleta, y citometr\u00eda de flujo de anexiona v.     * localizaci\u00f3n de prote\u00edna: microscopia con focal.     * an\u00e1lisis estad\u00edstico: test chi cuadrado y curvas kaplan meier.     bcl-xl se sobreexpresa en l\u00edneas celulares de c\u00e1ncer de pr\u00f3stata hormonorresistente, y en tejidos de pacientes con c\u00e1ncer de pr\u00f3stata indiferenciado, donde evidenciamos una relaci\u00f3n directa entre la expresi\u00f3n de bcl-xl, el grado de gleason y la progresi\u00f3n a hormonorrresistencia, en pacientes tratados con terapia de deprivaci\u00f3n androg\u00e9nica.     las mol\u00e9culas proapopt\u00f3ticas multidomino bax y bak no se expresan de manera significativamente diferente en relaci\u00f3n al grado de gleason.     comprobamos c\u00f3mo bcl-xl ejerce un mecanismo de bloqueo citos\u00f3lico sobre bax y bak, en c\u00e9lulas no estimuladas, implicado en la adquisi\u00f3n del fenotipo hormonorresistente.     la actividad antiapopt\u00f3tica de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los factores antiapopt\u00f3ticos bcl-xl y hsp60 en la progresi\u00f3n y hormonorresistencia del c\u00e1ncer de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los factores antiapopt\u00f3ticos bcl-xl y hsp60 en la progresi\u00f3n y hormonorresistencia del c\u00e1ncer de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Congregado Ruiz Carmen Belen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Saez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Casti\u00f1eiras fern\u00e1ndez <\/li>\n<li>Miguel \u00e1ngel Jap\u00f3n rodr\u00edguez (vocal)<\/li>\n<li>Jos\u00e9 Martinez (vocal)<\/li>\n<li>Javier Romero f. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Congregado Ruiz Carmen Belen Las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata sensibles a terapia con bloqueo hormonal androg\u00e9nico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1533,52,10715],"tags":[47265,168076,168077,20642,7198,141752],"class_list":["post-78148","post","type-post","status-publish","format-standard","hentry","category-cirugia-urologica","category-histopatologia","category-sevilla","tag-carmen-saez-torres","tag-congregado-ruiz-carmen-belen","tag-javier-romero-f","tag-jesus-castineiras-fernandez","tag-jose-Martinez","tag-miguel-angel-japon-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78148"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78148\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}