{"id":78152,"date":"2018-03-09T23:23:46","date_gmt":"2018-03-09T23:23:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-citoquina-il-1beta-incrementa-la-funcion-gabaergica-a-traves-de-pi3k-akt-relevancia-en-la-encefalopatia-asociada-al-sepsis\/"},"modified":"2018-03-09T23:23:46","modified_gmt":"2018-03-09T23:23:46","slug":"la-citoquina-il-1beta-incrementa-la-funcion-gabaergica-a-traves-de-pi3k-akt-relevancia-en-la-encefalopatia-asociada-al-sepsis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-citoquina-il-1beta-incrementa-la-funcion-gabaergica-a-traves-de-pi3k-akt-relevancia-en-la-encefalopatia-asociada-al-sepsis\/","title":{"rendered":"La citoquina il 1beta incrementa la funcion gabaergica a traves de pi3k akt. relevancia en la encefalopatia asociada al sepsis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rocio Serrantes Vergara <\/strong><\/h2>\n<p>La eas es una complicaci\u00f3n neurol\u00f3gica frecuente y temprana en los pacientes s\u00e9pticos que cursa con una reducida actividad cerebral y tiene una influencia negativa en la supervivencia; a pesar de ello, los estudios experimentales no han conseguido establecer su patog\u00e9nesis. Datos cl\u00ednicos previos de nuesro grupo obtenidos en pacientes s\u00e9pticos, con o sin encefalopat\u00eda mostraban una asociaci\u00f3n entre la elevaci\u00f3n de los niveles de il-1beta y la afectaci\u00f3n neurol\u00f3gica. Por ello en el presente trabajo establecimos como hip\u00f3tesis que il-1beta podr\u00eda contribuir a la g\u00e9nesis de la eas a trav\u00e9s de una alteraci\u00f3n de la transmisi\u00f3n sin\u00e1ptica cerebral. Nos centramos en la interacci\u00f3n de la citoquina con el receptor gabaa, el receptor que media la transmisi\u00f3n sin\u00e1ptica r\u00e1pida en la mayor\u00eda de las sinapsis inhibidoras de cerebro de mam\u00edferos. Para la realizaci\u00f3n de este trabajo hemos combinadouna serie de t\u00e9cnicas,  incluyendo las de inmunocitoqu\u00edmica y microscop\u00eda confocal, inmunoblot, electrofisiol\u00f3gicas y moleculares. Se han utilizado las neuronas de hipocampo en cultivo y los ovocitos de xenopus inyectados con mrna de cerebro de rata, dos modelos celulares que expresan receptores de gabaa nativos o for\u00e1neos, respectivamente. Im\u00e1genes confocales de neuronas o de ovocitos muestran que il-1beta incrementa la expresi\u00f3n de receptores gabaa en la superficie celular. M\u00e1s a\u00fan, breves pulsos de il-1beta aplicados en ovocitos produce una potenciaci\u00f3n de la corriente mediada por el receptor gabaa. Dicha potenciaci\u00f3n se instaura lentamente, en armon\u00eda con la progresiva redistribuci\u00f3n de los receptores gabaa en la superficie celular. En la b\u00fasqueda del mecanismo que conecta il-1beta con la redistribuci\u00f3n del receptor gabaa encontramos que la citoquina activa la v\u00eda pi3k\/akt, que a su vez, induce la translocaci\u00f3n del receptor gabaa a la superficie celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La citoquina il 1beta incrementa la funcion gabaergica a traves de pi3k akt. relevancia en la encefalopatia asociada al sepsis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La citoquina il 1beta incrementa la funcion gabaergica a traves de pi3k akt. relevancia en la encefalopatia asociada al sepsis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rocio Serrantes Vergara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Montiel L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Satr\u00fastegui gil-delgado <\/li>\n<li>pilar Gonzalez gonzalez (vocal)<\/li>\n<li>Carlos Matute almau (vocal)<\/li>\n<li>Jaime Renart pita (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rocio Serrantes Vergara La eas es una complicaci\u00f3n neurol\u00f3gica frecuente y temprana en los pacientes s\u00e9pticos que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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