{"id":78157,"date":"2018-03-09T23:23:46","date_gmt":"2018-03-09T23:23:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-farmacocinetica-de-farmacos-antiretrovirales-desarrollo-de-la-tecnica-analitica-y-utilidad-clinica\/"},"modified":"2018-03-09T23:23:46","modified_gmt":"2018-03-09T23:23:46","slug":"determinacion-farmacocinetica-de-farmacos-antiretrovirales-desarrollo-de-la-tecnica-analitica-y-utilidad-clinica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-farmacocinetica-de-farmacos-antiretrovirales-desarrollo-de-la-tecnica-analitica-y-utilidad-clinica\/","title":{"rendered":"Determinacion farmacocinetica de farmacos antiretrovirales desarrollo de la tecnica analitica y utilidad clinica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andres Navarro Ruiz <\/strong><\/h2>\n<p>El objetivo principal de este trabajo fue desarrollar una t\u00e9cnica analitica para determinar las concentraciones plasm\u00e1tica de lopanavir y efavirenz. como objetivos secundarios se analiz\u00f3 la relaci\u00f3n entre las concentraciones plasm\u00e1ticas del inhibidor de la proteasa (ip) lopanavir y su eficacia virol\u00f3gica y  efectos adversos y, la relaci\u00f3n entre concentraciones plasm\u00e1ticas del inhibidor de la transcriptasa inversa no an\u00e1logo de los nucle\u00f3ticos (itinn) efavirenz y alteraciones de los par\u00e1metros hep\u00e1ticos y efectos adversos neuropsiqui\u00e1tricos. Las determinaciones de los f\u00e1rmacos se realizaron mediante cromatrograf\u00eda l\u00edquida de alta resoluci\u00f3n. El estudio cl\u00ednico fue un  estudio prospectivo longitudinal de un grupo de pacientes tratados con lopinavir\/ritonavir en fracaso virol\u00f3gico con otras pautas de tratamiento antriretroviral y, otro grupo de pacientes tratados con efavirenz m\u00e1s dos  an\u00e1logos de transcriptasa inversa an\u00e1logos de nucle\u00f3sidos con carga viral indetectable. La t\u00e9cnica anal\u00edtica desarrollada permiti\u00f3, en tan solo 90, un procesado de la muestra desde la extracci\u00f3n a la determinaci\u00f3n. La exactitud determinada a trav\u00e9s del error relativo fue del orden del 6,5%. La precisi\u00f3n, medida mediante el coeficiente de variaci\u00f3n , intra e interensayo, fue inferior al 8%. las curvas est\u00e1ndar de los f\u00e1rmacos fueron lineales en el rango de concentraciones ensayado, con coeficientes de correlaci\u00f3n superiores a  r  igual a 0.9977. a dosis terape\u00faticas las concentraciones plasm\u00e1ticas de lopinavir y efavirenz oscilaron entre 1 a 10 mcg\/ml y 1 a 5 mcg\/ml respectivamente. Los pacientes incluidos en el grupo de lopinavir alcanzaron valores de  concentraciones plasm\u00e1ticas muy superiores a la concentraci\u00f3n inhibitoria del 50% para la cepa silvestre del vih. La respuesta virol\u00f3gica e inmunol\u00f3gica fue robusta en el 47% de los pacientes y el 32% alcanz\u00f3 una carga viral indetectable. la respuesta fue mayor en los pac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion farmacocinetica de farmacos antiretrovirales desarrollo de la tecnica analitica y utilidad clinica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion farmacocinetica de farmacos antiretrovirales desarrollo de la tecnica analitica y utilidad clinica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andres Navarro Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felix Gutierrez Rodero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li>victoria Calvo hernandez (vocal)<\/li>\n<li>joaquin Borras tortonda (vocal)<\/li>\n<li>federico Pulido ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andres Navarro Ruiz El objetivo principal de este trabajo fue desarrollar una t\u00e9cnica analitica para determinar las 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