{"id":78225,"date":"2018-03-09T23:23:50","date_gmt":"2018-03-09T23:23:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/homeostasis-del-calcio-en-plaquetas-de-ratas-cirroticas\/"},"modified":"2018-03-09T23:23:50","modified_gmt":"2018-03-09T23:23:50","slug":"homeostasis-del-calcio-en-plaquetas-de-ratas-cirroticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/homeostasis-del-calcio-en-plaquetas-de-ratas-cirroticas\/","title":{"rendered":"Homeostasis del calcio en plaquetas de ratas cirroticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Iy\u00fa Espinosa <\/strong><\/h2>\n<p>Estudios previos de nuestro laboratorio han demostrado un aumento del \u00f3xido n\u00edtrico (no) en ratas cirr\u00f3ticas por ligadura del conducto biliar (lcs), mediante la utilizaci\u00f3n de inhibidores de su s\u00edntesis (ram\u00edrez, 1995). en esta misma l\u00ednea nuestro laboratorio dispone de muchos datos que indican que el no interfiere de forma muy importante con los mecanismos de regulaci\u00f3n de la concentraci\u00f3n de ca2+ intracelular en la pared vascular. As\u00ed, en experimentos en los que se utiliz\u00f3 el lecho arterial mesent\u00e9rico, aislado y perfundido, de ratas sometidas a lcs, se comprob\u00f3 que tanto la entrada de ca2+, a trav\u00e9s de diversos canales, como la liberaci\u00f3n de este desde los dep\u00f3sitos intemos era menor en las ratas sometidas a lcs (nadal y cols., 2002). Para profundizar m\u00e1s en estas alteraciones, nuestro laboratorio ha realizado estudios con c\u00e9lulas musculares lisas, aisladas de la aorta abdominal, de ratas sometidas a lcs, confirmando que tanto la entrada de ca2+ extracelular, como la liberaci\u00f3n desde los dep\u00f3sitos es menor en las c\u00e9lulas musculares de las ratas lcs (atucha y cols., 2003). En ambos casos, el uso de inhibidores de la sintasa de no mejor\u00f3 la respuesta del ca2+, confirmando el papel del no en la regulaci\u00f3n de sus niveles y el origen muscular, adem\u00e1s, de endotelial de la producci\u00f3n del no. En muchos estudios cardiovasculares se han utilizado las plaquetas como un modelo f\u00e1cilmente obtenible que sirve para analizar de forma comparativa algunas de las propiedades de las c\u00e9lulas musculares lisas. Asi, se han relacionado los aumentos del ca2+ en las plaquetas con la hipertensi\u00f3n (eme y cols., 1984). En nuestro modelo de ratas lcs, al igual que en otros tipos de cirrosis, existe una circulaci\u00f3n hiperdin\u00e1mica, con vasodilataci\u00f3n generalizada; de este modo, ser\u00eda interesante estudiar la se\u00f1al celular del ca2+ en las plaquetas, al objeto de comprobar si ocurren las mismas  alteraciones que las descritas para las c\u00e9<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Homeostasis del calcio en plaquetas de ratas cirroticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Homeostasis del calcio en plaquetas de ratas cirroticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Iy\u00fa Espinosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Esta\u00f1 L\u00f3pez Joaquin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 f\u00e9lix Vargas palomares <\/li>\n<li> Garc\u00eda del r\u00edo cipriano (vocal)<\/li>\n<li> Garc\u00eda borr\u00f3n mart\u00ednez Jos\u00e9 Carlos (vocal)<\/li>\n<li>salvador Ruiz lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Iy\u00fa Espinosa Estudios previos de nuestro laboratorio han demostrado un aumento del \u00f3xido n\u00edtrico (no) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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