{"id":78314,"date":"2018-03-09T23:23:58","date_gmt":"2018-03-09T23:23:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-de-las-citoquinas-y-de-la-sintetasa-del-oxido-nitrico-nos-y-su-expresion-en-pacientes\/"},"modified":"2018-03-09T23:23:58","modified_gmt":"2018-03-09T23:23:58","slug":"polimorfismos-de-las-citoquinas-y-de-la-sintetasa-del-oxido-nitrico-nos-y-su-expresion-en-pacientes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-de-las-citoquinas-y-de-la-sintetasa-del-oxido-nitrico-nos-y-su-expresion-en-pacientes\/","title":{"rendered":"Polimorfismos de las citoquinas y de la sintetasa del oxido nitrico (nos) y su expresi\u00f3n en pacientes"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lopez Anglada Fernandez Esteban <\/strong><\/h2>\n<p>Introducci\u00f3n  las citocinas y el enzima sintasa del \u00f3xido n\u00edtrico (nos) se relacionan en numerosas publicaciones con el aflojamiento as\u00e9ptico de las pr\u00f3tesis as\u00ed como con otras patolog\u00edas que afectan al metabolismo del hueso.  estas mol\u00e9culas se sabe que son polim\u00f3rficas. Los polimorfismos gen\u00e9ticos son una fuente de variabilidad gen\u00e9tica y se ha visto que ciertos genotipos de determinados genes polim\u00f3rficos pueden estar relacionados con el riesgo a padecer algunas enfermedades. En el caso del aflojamiento as\u00e9ptico los polimorfismos de estas mol\u00e9culas pueden estar relacionados con el riesgo a presentar aflojamiento as\u00e9ptico, as\u00ed como con la caracter\u00edstica variedad de patrones evolutivos de esta patolog\u00eda.  objetivos  se pretende estudiar la frecuencia de los polimorfismos de las citocinas il-1a(-889 c\/t), il-1beta(+3954 t\/c), receptor para la il-1 (il-1rn; repetici\u00f3n de 86 pb, intr\u00f3n 2), tnf-alfa (-308 g\/a), tnf-alfa (-238 g\/a) y de la encima sintasa del \u00f3xido n\u00edtrico endotelial (enos: repetici\u00f3n de 27 pb en el intr\u00f3n 4, y enos,y enos: -786t\/c), e inducible (inos:inos22 g\/a) en 53 pacientes con aflojamiento as\u00e9ptico de pr\u00f3tesis de cadera y de rodilla, compar\u00e1ndolos con un grupo control constituido por 129 pacientes con artrosis de cadera o de rodilla. Adem\u00e1s se pretende estudiar la expresi\u00f3n de estos genes polim\u00f3rficos mediante la determinaci\u00f3n en suero de il-1a y beta, il-6, tnf-a y nitritos\/nitratos (nox), as\u00ed como la expresi\u00f3n de nos en el tejido \u00f3seo.  material y m\u00e9todo  se trabaj\u00f3 sobre muestras de sangre perif\u00e9rica de cuyos leucocitos se obtuvo el \u00e1cido desoxirribonucl\u00e9ico (adn). Mediante t\u00e9cnicas de pcr se amplific\u00f3 el adn y se realiz\u00f3 el genotipado de los distintos polimorfismos. Sobre estas muestras de sangre tambi\u00e9n se llev\u00f3 a cabo la determinaci\u00f3n de los niveles de citocinas y nox en el laboratorio de bioqu\u00edmica molecular. Finalmente se realiz\u00f3 una tinci\u00f3n inmunohistoqu\u00edmic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos de las citoquinas y de la sintetasa del oxido nitrico (nos) y su expresi\u00f3n en pacientes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos de las citoquinas y de la sintetasa del oxido nitrico (nos) y su expresi\u00f3n en pacientes <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lopez Anglada Fernandez Esteban <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Paz Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor Asensi alvarez <\/li>\n<li>Luis Mar\u00eda Ferrandez portal (vocal)<\/li>\n<li>enrique Martinez rodr\u00edguez (vocal)<\/li>\n<li>Jos\u00e9 ramiro Prieto  monta\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lopez Anglada Fernandez Esteban Introducci\u00f3n las citocinas y el enzima sintasa del \u00f3xido n\u00edtrico (nos) se relacionan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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