{"id":78315,"date":"2018-03-09T23:23:58","date_gmt":"2018-03-09T23:23:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-de-citocinas-y-de-la-sintasa-del-oxido-nitrico-en-las-fracturas-de-cuello\/"},"modified":"2018-03-09T23:23:58","modified_gmt":"2018-03-09T23:23:58","slug":"polimorfismos-geneticos-de-citocinas-y-de-la-sintasa-del-oxido-nitrico-en-las-fracturas-de-cuello","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-de-citocinas-y-de-la-sintasa-del-oxido-nitrico-en-las-fracturas-de-cuello\/","title":{"rendered":"Polimorfismos gen\u00e9ticos de citocinas y de la sintasa del oxido nitrico en las fracturas de cuello"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Solis Gomez M. Angeles <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico (no) es mediador de p\u00e9rdida \u00f3sea a trav\u00e9s de citocinas inductoras de inflamaci\u00f3n. La isoforma endotelial (nos3) e inducible (nos2) de la \u00f3xido n\u00edtrico sintasa (nos) se expresan en los osteoblastos e influyen en la maduraci\u00f3n \u00f3sea. Diversos polimorfismos de los genes de la nos se asocian a elevaci\u00f3n de los niveles s\u00e9ricos de no que pueden contribuir a la causa de patolog\u00edas \u00f3seas como las fracturas de cadera.  se ha estudiado una potencial asociaci\u00f3n entre las fracturas de cadera y ciertos polimorfimos de la nos (nos3: repetici\u00f3n de 27 pb en el intr\u00f3n 4, promotor -786t\/c y nos2 ex\u00f3n 22) e interlecuinas (il1a-889, ul1beta+3954 e il1ra repetici\u00f3n de 89pb). La homocigosis de los genes nos3-4 repeticiones de 27pb e il1beta-3954 tt son significativamente m\u00e1s frecuentes en 111 pacientes con fractura de cada era respecto a 127 controles sanos. Los niveles de no se midieron en suero y fueron significativamente m\u00e1s elevados en los pacientes con fractura, as\u00ed como los niveles s\u00e9ricos de il6. Hemos descrito por primera vez una asociaci\u00f3n entre los polimorfismos de la nos3 y la il1beta y la fractura de cadera, aunque se debe esperar nuevos estudios que lo confirmen.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos gen\u00e9ticos de citocinas y de la sintasa del oxido nitrico en las fracturas de cuello<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos gen\u00e9ticos de citocinas y de la sintasa del oxido nitrico en las fracturas de cuello <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Solis Gomez M. Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Paz Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Martinez rodr\u00edguez <\/li>\n<li>Jos\u00e9 ramiro Prieto  monta\u00f1a (vocal)<\/li>\n<li>Luis Mar\u00eda Ferrandez portal (vocal)<\/li>\n<li>eulalia Valle garay (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Solis Gomez M. Angeles El \u00f3xido n\u00edtrico (no) es mediador de p\u00e9rdida \u00f3sea a trav\u00e9s de citocinas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,141,4233,11771,8846],"tags":[8848,123949,27899,77381,9591,168374],"class_list":["post-78315","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-cirugia","category-cirugia-ortopedica","category-genetica-clinica","category-oviedo","tag-enrique-Martinez-rodriguez","tag-eulalia-valle-garay","tag-jose-paz-jimenez","tag-jose-ramiro-prieto-montana","tag-luis-maria-ferrandez-portal","tag-solis-gomez-m-angeles"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78315"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78315\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}