{"id":7832,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/efecto-de-la-suramina-sobre-lineas-celulares-tumorales-humanas\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"efecto-de-la-suramina-sobre-lineas-celulares-tumorales-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-suramina-sobre-lineas-celulares-tumorales-humanas\/","title":{"rendered":"Efecto de la suramina sobre lineas celulares tumorales humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Lopez Lopez <\/strong><\/h2>\n<p>La suramina, una vieja droga antiparasitaria, esta recobrando interes en el mundo de la oncolog\u00eda por sus inusuales mecanismos de accion y respuestas en tumores no sensibles como en el adenocarcinoma de prostata. Con el fin de profundizar mas en las acciones y en el mecanismo de accion se realizo este trabajo doctoral estudiando in vitro el efecto de la suramina sobre lineas celulares tumorales humanas, centrandose en la linea pc3 y mcf-7, derivadas de un adenocarcinoma de prostata y de un adenocarcinoma de mama, respectivamente.  la concentracion de suramina que inhibio el 50% del crecimiento fue menor de 200 um en todas las lineas estudiadas y fue dependiente del tiempo de exposicion. La cantidad de proteinas en el medio de cultivo disminuyo los efectos de la suramina. La combinacion de suramina con cisplatino y el factor de necrosis tumoral fue sinergica en pc3 y mcf-7. El pre y postratamiento con adriamicina y el postratamiento con camptotecina fue sinergico. El calcio intracelular, la protein-kinasa c y la adenilciclasa son inhibidos por la suramina de forma dosis dependiente. La suramina arresta las celulas en la fase g1 del ciclo celular y disminuye la expresion de los genes de las topoisomerasas i y ii, sin afectar a la actividad de la topoisomerasa i.  estos resultados sugieren la posibilidad de estudiar la suramina en tumores como cancer de cabeza y cuello, mama, pulmon y colon. La union a proteinas fue el determinante mayor de la inhibicion del tratamiento, no siendo este afectado por los factores de crecimiento exogenos. La importancia del esquema de administracion y de la eleccion de diferentes drogas para utilizarla en combinacion en ensayos clinicos se debe valorar con precaucion. La afectacion de las vias de se\u00f1ales y de las topoisomerasas abre nuevos caminos en la comprension del mecanismo de accion y terapeuticos en la utilizacion de la suramina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la suramina sobre lineas celulares tumorales humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la suramina sobre lineas celulares tumorales humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Lopez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mateos Otero Juan  Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Cesar Aguirre Viani <\/li>\n<li> Buesa Perez Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li> Represa De La Guerra Juan (vocal)<\/li>\n<li>Antonio Virizuela Echaburu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Lopez Lopez La suramina, una vieja droga antiparasitaria, esta recobrando interes en el mundo de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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