{"id":78345,"date":"2018-03-09T23:23:58","date_gmt":"2018-03-09T23:23:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/investigacion-precunica-de-nuevos-farmacos-inhibidores-de-la-reabsorcion-intestinal-y-captacion-hepatica-de-acidos-biliares-utilidad-en-hipercolesterolemia\/"},"modified":"2018-03-09T23:23:58","modified_gmt":"2018-03-09T23:23:58","slug":"investigacion-precunica-de-nuevos-farmacos-inhibidores-de-la-reabsorcion-intestinal-y-captacion-hepatica-de-acidos-biliares-utilidad-en-hipercolesterolemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/investigacion-precunica-de-nuevos-farmacos-inhibidores-de-la-reabsorcion-intestinal-y-captacion-hepatica-de-acidos-biliares-utilidad-en-hipercolesterolemia\/","title":{"rendered":"Investigacion precunica de nuevos farmacos inhibidores de la reabsorcion intestinal y captacion hepatica de acidos biliares. utilidad en hipercolesterolemia"},"content":{"rendered":"

Tesis doctoral de Marta Vicens Manero <\/strong><\/h2>\n

En este trabajo de tesis doctoral se ha investigado la capacidad hipocolesterolemiante de tres derivados de \u00e1cidos biliares que denominamos bapas (\u00abbile acid polyamine\u00bb). La hip\u00f3tesis fue que estos compuestos podr\u00edan inhibir la reabsorci\u00f3n ileal de los \u00e1cidos biliares naturales sin secuestrarlos de la luz intestinal, estimulando la conversi\u00f3n del colesterol en nuevos \u00e1cidos biliares y reduciendo, de este modo, las concentraciones s\u00e9ricas de colesterol. La s\u00edntesis de los compuestos se realiz\u00f3 mediante la formaci\u00f3n de enlaces amida entre el grupo carboxilo del \u00e1cido glicoc\u00f3lico y los grupos amino de la n(3-aminopropil)-1,3-propanodiamina. Los bapas han demostrado capacidad de inhibir el transporte ileal y hep\u00e1tico de los \u00e1cidos biliares en diferentes modelos experimentales tanto \u00abin vitro\u00bb; en el modelo de expresi\u00f3n de prote\u00ednas transportadoras de membrana en oocitos de rana xenopus laevis, en el que en algunos casos se lleg\u00f3 a reducir la captaci\u00f3n hasta un 80%, como \u00abin vivo\u00bb; en el modelo de \u00edleon de rata perfundido \u00abin situ\u00bb, en el que se comprob\u00f3 que aunque compet\u00edan por los transportadores intestinales de \u00e1cidos biliares, ellos mismos presentaban una pobre absorci\u00f3n por la mucosa ileal. la administraci\u00f3n de los bapas a ratones redujo de forma significativa el \u00abpool\u00bb total de \u00e1cidos biliares, sin que aparecieran efectos t\u00f3xicos a nivel hep\u00e1tico ni renal a las dosis ensayadas. El tratamiento con los bapas modific\u00f3 la expresi\u00f3n g\u00e9nica de las principales enzimas hep\u00e1ticas responsables de la s\u00edntesis de \u00e1cidos biliares y colesterol, y de los transportadores de \u00e1cidos biliares hep\u00e1ticos e intestinales como consecuencia de la ca\u00edda del \u00abpool\u00bb de \u00e1cidos bilares. en resumen, la capacidad de los bapas de inhibir la absorci\u00f3n intestinal de los \u00e1cidos biliares disminuyendo el tama\u00f1o del \u00abpool\u00bb de estos aniones org\u00e1nicos y la ausencia de efectos adversos sugieren que podr\u00edan ser \u00fatiles en el tratamiento de la hipercolesterolemia<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abInvestigacion precunica de nuevos farmacos inhibidores de la reabsorcion intestinal y captacion hepatica de acidos biliares. utilidad en hipercolesterolemia<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion precunica de nuevos farmacos inhibidores de la reabsorcion intestinal y captacion hepatica de acidos biliares. utilidad en hipercolesterolemia <\/li>\n
  • Autor:<\/strong>\u00a0 Marta Vicens Manero <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 20\/01\/2006<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Rocio Rodriguez Macias<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: jose Vazquez tato <\/li>\n
        • felipe alfonso Jimenez vicente (vocal)<\/li>\n
        • Luis Fontana gallego (vocal)<\/li>\n
        • —– —– (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Marta Vicens Manero En este trabajo de tesis doctoral se ha investigado la capacidad hipocolesterolemiante de tres […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2445,3304,9386],"tags":[81556,2863,127112,168435,168436],"class_list":["post-78345","post","type-post","status-publish","format-standard","hentry","category-evaluacion-de-farmacos","category-preparacion-de-farmacos","category-salamanca","tag-felipe-alfonso-jimenez-vicente","tag-jose-vazquez-tato","tag-luis-fontana-gallego","tag-marta-vicens-manero","tag-rocio-rodriguez-macias"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78345"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78345\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}