{"id":78351,"date":"2018-03-09T23:23:58","date_gmt":"2018-03-09T23:23:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eliminacion-de-beta-lactamicos-y-enoxaparina-en-pacientes-cra%c2%adticos-sometidos-a-tecnicas-continuas-de-reemplazo-renal\/"},"modified":"2018-03-09T23:23:58","modified_gmt":"2018-03-09T23:23:58","slug":"eliminacion-de-beta-lactamicos-y-enoxaparina-en-pacientes-cra%c2%adticos-sometidos-a-tecnicas-continuas-de-reemplazo-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/eliminacion-de-beta-lactamicos-y-enoxaparina-en-pacientes-cra%c2%adticos-sometidos-a-tecnicas-continuas-de-reemplazo-renal\/","title":{"rendered":"Eliminaci\u00f3n de beta-lact\u00e1micos y enoxaparina en pacientes cr\u00edticos sometidos a t\u00e9cnicas continuas de reemplazo renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arantxazu Isla Ruiz <\/strong><\/h2>\n<p>En las \u00faltimas d\u00e9cadas se han producido avances significativos en el desarrollo de diferentes m\u00e9todos para la sustituci\u00f3n de la funci\u00f3n renal. Las t\u00e9cnicas continuas de reemplazo renal (crrt) en concreto, han evolucionado notablemente y se considera uno de los avances m\u00e1s importantes de los \u00faltimos a\u00f1os con medicina intensiva. Por normal general su uso no esta orientado a la eliminaci\u00f3n de f\u00e1rmacos, pero es importante determinar en qu\u00e9 medida se eliminan a trav\u00e9s de las membranas para optimizar los reg\u00edmenes posol\u00f3gicos y garantizar la eficacia de los tratamientos. Por ello, este trabajo estudia la farmacocin\u00e9tica de diferentes antibi\u00f3ticos: ceftazidima, cefepima y meropenem, y la eliminaci\u00f3n extracorp\u00f3rea de una heparina de bajo peso molecular: enoxaparina, cuando se aplican crrt. Para cada mol\u00e9cula se han llevado a cabo estudios in vitro e in vivo.     1,- en los ensayos in vitro se eval\u00faa la permeabilidad de dos membranas diferntes (an69 y polisulfona) a cada mol\u00e9cula durante hemofiltraci\u00f3n continua y hemodi\u00e1lisis continua, empleando como veh\u00edculo de los f\u00e1rmacos en el circuito soluci\u00f3n ringer lactado, ringer lactato con alb\u00famina bovina y plasma fresco humano.    2,- en los ensayos in vivo se han incluido 4 pacientes sometidos a hemofiltraci\u00f3n continua veno-venosa o hemodiafiltraci\u00f3n continua veno-venosa para el estudio de ceftazidima, otros 4 para el de cefepima, 20 para el de meropenem y 8 para el de enoxaparina.     los tres antibi\u00f3ticos se eliminan de forma significativa mediante crrt. La permeabilidad de las dos membranas es a similar para cada cantimicrobinao, y no var\u00eda con la t\u00e9cnica empleada (henmofiltraci\u00f3n o hemodi\u00e1lisis). Se debe tener en cuenta la contribuci\u00f3n del aclaramiento extracorp\u00f3reo a aclaramiento total a la hora de establecer los reg\u00edmenes de dosificaci\u00f3n m\u00e1s adecuados para tratar con ceftazidmia, cefepima y meorpenem pacientes criticos sometidos a crrt. En el estudio de meropenem se observa adem<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eliminaci\u00f3n de beta-lact\u00e1micos y enoxaparina en pacientes cr\u00edticos sometidos a t\u00e9cnicas continuas de reemplazo renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eliminaci\u00f3n de beta-lact\u00e1micos y enoxaparina en pacientes cr\u00edticos sometidos a t\u00e9cnicas continuas de reemplazo renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arantxazu Isla Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>Andr\u00e9s Canut blasco (vocal)<\/li>\n<li>Jos\u00e9 ignacio Fernandez de troconiz (vocal)<\/li>\n<li>e. Peris jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arantxazu Isla Ruiz En las \u00faltimas d\u00e9cadas se han producido avances significativos en el desarrollo de diferentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2445,12909,14986],"tags":[3222,95330,168444,168445,51407,3308],"class_list":["post-78351","post","type-post","status-publish","format-standard","hentry","category-evaluacion-de-farmacos","category-pais-vasco-euskal-herriko-unibertsitatea","category-tecnologia-de-antibioticos","tag-alfonso-jesus-dominguez-gil-hurle","tag-andres-canut-blasco","tag-arantxazu-isla-ruiz","tag-e-peris-jose","tag-jose-ignacio-fernandez-de-troconiz","tag-jose-luis-pedraz-munoz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78351"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78351\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}