{"id":78383,"date":"2018-03-09T23:24:02","date_gmt":"2018-03-09T23:24:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trypanosoma-cruzi-nuevos-metodos-colorimetricos-de-cribado-y-alternativas-terapeuticas\/"},"modified":"2018-03-09T23:24:02","modified_gmt":"2018-03-09T23:24:02","slug":"trypanosoma-cruzi-nuevos-metodos-colorimetricos-de-cribado-y-alternativas-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trypanosoma-cruzi-nuevos-metodos-colorimetricos-de-cribado-y-alternativas-terapeuticas\/","title":{"rendered":"Trypanosoma cruzi: nuevos m\u00e9todos colorim\u00e9tricos de cribado y alternativas terap\u00e9uticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vega G\u00f3mez Mar\u00eda Celeste <\/strong><\/h2>\n<p>Seg\u00fan la oms se estima que entre 18 a 20 millones de personas padecen esta enfermedad. Teniendo en cuenta que cuenta que puede ser mortal tanto en su fase aguda (2-8%, principalmente poblaci\u00f3n infantil) como en la cr\u00f3nica (20%), es l\u00f3gica la preocupaci\u00f3n que esta parasistosis suscita entre las autoridades sanitarias de los pa\u00edses afectados. Para el tratamiento de la enfermedad los f\u00e1rmacos empleados son principalmente dos: nifurtimox y benzonidazol. Ambos eliminan los s\u00edntomas si se administran durante la fase aguda, acortando el curso de la infecci\u00f3n, pero tienen escasa actividad en la fase cr\u00f3nica. Adem\u00e1s existen cepas resistentes incluso en la fase inicial de la enfermedad. Estos factores determinan que las dosis administradas y la duraci\u00f3n del tratamiento sean elevadas, lo que facilita la aparici\u00f3n de importantes efectos secundarios, que obligan en muchos casos a suspender el mismo. Dada esta situaci\u00f3n, se mantiene un campo abierto para la investigaci\u00f3n de sustitutos, cuyos beneficios en t\u00e9rminos econ\u00f3micos y sociales son de vital importancia. desgraciadamente y a pesar del gran n\u00famero de compuestos ensayados, pocos han alcanzado la fase cl\u00ednica. Ante la escasez de alternativas, es evidente la urgente necesidad de desarrollar nuevos f\u00e1rmacos. Los m\u00e9todos para el cribado farmacol\u00f3gico de nuevos productos son numerosos y variados. En este aspecto, el desarrollo de modelos \u00abin vitro\u00bb supuso un gran avance respecto a las pruebas \u00abin vivo\u00bb, al disminuir considerablemente el tiempo invertido y el coste de las t\u00e9cnicas. pero la cuantificaci\u00f3n de los par\u00e1sitos y la reproducibilidad siguen siendo un problema en las t\u00e9cnicas de uso habitual.     algunos de los m\u00e9todos disponibles son especialmente laboriosos, principalmente las t\u00e9cnicas de cribado sobre amastigotes intracelulares, que en general emplean el recuento microsc\u00f3pico para la evaluaci\u00f3n de la actividad de un compuesto. Vali\u00e9ndonos del notable impulso que la biotecnolog\u00eda ha pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trypanosoma cruzi: nuevos m\u00e9todos colorim\u00e9tricos de cribado y alternativas terap\u00e9uticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trypanosoma cruzi: nuevos m\u00e9todos colorim\u00e9tricos de cribado y alternativas terap\u00e9uticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vega G\u00f3mez Mar\u00eda Celeste <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alicia G\u00f3mez Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  ramon Martinez fernandez <\/li>\n<li> Aran redo vicente Jes\u00fas (vocal)<\/li>\n<li>Rafael Martinez diaz (vocal)<\/li>\n<li>consuelo Gimenez pardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vega G\u00f3mez Mar\u00eda Celeste Seg\u00fan la oms se estima que entre 18 a 20 millones de personas 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