{"id":78400,"date":"2018-03-09T23:24:02","date_gmt":"2018-03-09T23:24:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-inhalacion-cronica-de-mptp-induce-parkinsonismo-y-respuesta-antioxidante-en-raton-papel-de-la-va%c2%ada-pi3k-akt-en-la-regulacion-del-enzima-cu-zn-superoxido-dismutasa\/"},"modified":"2018-03-09T23:24:02","modified_gmt":"2018-03-09T23:24:02","slug":"la-inhalacion-cronica-de-mptp-induce-parkinsonismo-y-respuesta-antioxidante-en-raton-papel-de-la-va%c2%ada-pi3k-akt-en-la-regulacion-del-enzima-cu-zn-superoxido-dismutasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-inhalacion-cronica-de-mptp-induce-parkinsonismo-y-respuesta-antioxidante-en-raton-papel-de-la-va%c2%ada-pi3k-akt-en-la-regulacion-del-enzima-cu-zn-superoxido-dismutasa\/","title":{"rendered":"La inhalaci\u00f3n cr\u00f3nica de mptp induce parkinsonismo y respuesta antioxidante en rat\u00f3n. papel de la v\u00edapi3k\/akt en la regulaci\u00f3n del enzima cu\/zn-super\u00f3xido dismutasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Rojo Sanchis <\/strong><\/h2>\n<p>El origen de la enfermedad de parkinson todav\u00eda no se conoce con detalle, pero estudios epidemiol\u00f3gicos sugieren que las toxinas ambientales son un importante factor de riesgo. Sin embargo esta hip\u00f3tesis no est\u00e1 formalmente demostrada porque los modelos desarrollados en animales de experimentaci\u00f3n se basan en la entrada de las toxinas atrav\u00e9s de de v\u00edas de entrada no naturales. En este trabajo desarrollamos por primera vez un nuevo modelo para le enfermedad de parkinson en rat\u00f3n basado en la inoculaci\u00f3n intranasal cr\u00f3nica de mptp.  trabajos previos del grupo muestran que la quinasa akt juega un importante papel como sensor de estr\u00e9s oxidativo, sin embargo los mecanismos moleculares no han sido dilucidados con detalle. En esta tesis mostramos como al menos en parte akt ejerce su papel antioxidante induciendo la trasncripci\u00f3n del enzima sod-1 atrav\u00e9s de la regulaci\u00f3n del factor de transcripci\u00f3n nf-kb.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La inhalaci\u00f3n cr\u00f3nica de mptp induce parkinsonismo y respuesta antioxidante en rat\u00f3n. papel de la v\u00edapi3k\/akt en la regulaci\u00f3n del enzima cu\/zn-super\u00f3xido dismutasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La inhalaci\u00f3n cr\u00f3nica de mptp induce parkinsonismo y respuesta antioxidante en rat\u00f3n. papel de la v\u00edapi3k\/akt en la regulaci\u00f3n del enzima cu\/zn-super\u00f3xido dismutasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Rojo Sanchis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Cuadrado Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Sillero repullo <\/li>\n<li>Emilio Fernandez espejo (vocal)<\/li>\n<li> Marinissen manzano Mar\u00eda  julia (vocal)<\/li>\n<li>carmen Cavada Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Rojo Sanchis El origen de la enfermedad de parkinson todav\u00eda no se conoce con detalle, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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