{"id":78411,"date":"2018-03-09T23:24:02","date_gmt":"2018-03-09T23:24:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-funcionalidad-renal-en-la-farmacocinetica-de-piperacilina-tazobactam-en-pacientes-cra%c2%adticos-sometidos-a-hemofiltracion-venovenosa-continua\/"},"modified":"2018-03-09T23:24:02","modified_gmt":"2018-03-09T23:24:02","slug":"influencia-de-la-funcionalidad-renal-en-la-farmacocinetica-de-piperacilina-tazobactam-en-pacientes-cra%c2%adticos-sometidos-a-hemofiltracion-venovenosa-continua","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/influencia-de-la-funcionalidad-renal-en-la-farmacocinetica-de-piperacilina-tazobactam-en-pacientes-cra%c2%adticos-sometidos-a-hemofiltracion-venovenosa-continua\/","title":{"rendered":"Influencia de la funcionalidad renal en la farmacocin\u00e9tica de piperacilina\/tazobactam en pacientes cr\u00edticos sometidos a hemofiltraci\u00f3n venovenosa continua"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alazne Arzuaga Munsuri <\/strong><\/h2>\n<p>El objetivo de esta memoria experimental ha sido la evaluaci\u00f3n de la eliminaci\u00f3n extracorp\u00f3rea de piperacilina\/tazobactam en pacientes cr\u00edticos con diferente grado de disfunci\u00f3n renal sometidos a t\u00e9cnicas de reemplazo renal continuo. la farmacocin\u00e9tica de piperacilina\/tazobactam (4g\/0.5g cada 8, 6 \u00f3 4h, administrada mediante perfusi\u00f3n in de 20 min) se ha estudiado en diecis\u00e9is pacientes sometidos a hemofiltraci\u00f3n venovenosa continua. Los pacientes se agruparon en funci\u00f3n del grado de insuficiencia renal (clcr menor 10 ml\/min: 10 menor clcr menor 50 ml\/min and clcr mayor 50 ml\/min). Por otro lado, se han desarrollado m\u00e9todos de hplc simples y reproducibles para la determinaci\u00f3n de piperacilina y tazobactam y se ha realizado un estudio de estabilidad completo. El ajuste de los datos se ha realizado siguiendo los modelos compartimental y no-compartimental. La fracci\u00f3n de eliminaci\u00f3n o sieving coefficient (sc) de piperacilina y tazobactam ha resultado ser independiente del grado de insuficiencia renal. El sc de tazabactam fue similar a la fracci\u00f3n de f\u00e1rmaco libre en plasma. Sin embargo, el sc de piperacilina result\u00f3 ser significativamente inferior a la fracci\u00f3n no unida a prote\u00ednas plasm\u00e1ticas. asimismo, se ha visto que cuanto mayor es el grado de insuficiencia renal, mayor es la contribuci\u00f3n de la t\u00e9cnica extracorp\u00f3rea a la eliminaci\u00f3n de piperacilina y tazobactam. Por otro lado, no se ha observado acumulaci\u00f3n de tazobactam en ninguno de los pacientes. Adem\u00e1s, la administraci\u00f3n de piperacilina cada 4 horas en aquellos pacientes con clcr mayor 50 ml\/min, proporciona valores de tiempo supera cmo m\u00e1s favorables que los obtenidos con la administraci\u00f3n de piperacilina cada 6 horas, lo que incrementa la probabilidad de \u00e9xito del tratamiento contra los microorganismos que presentan cmi m\u00e1s elevadas. Por \u00faltimo, el estudio in vitro ha revelado que la membrana de polisulfona es m\u00e1s permeable a piperacilina y tazobactam que la membrana de an<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la funcionalidad renal en la farmacocin\u00e9tica de piperacilina\/tazobactam en pacientes cr\u00edticos sometidos a hemofiltraci\u00f3n venovenosa continua<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la funcionalidad renal en la farmacocin\u00e9tica de piperacilina\/tazobactam en pacientes cr\u00edticos sometidos a hemofiltraci\u00f3n venovenosa continua <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alazne Arzuaga Munsuri <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carla Caramella <\/li>\n<li>rosario Calvo (vocal)<\/li>\n<li>Jos\u00e9 Morais (vocal)<\/li>\n<li>eduardo Mari\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alazne Arzuaga Munsuri El objetivo de esta memoria experimental ha sido la evaluaci\u00f3n de la eliminaci\u00f3n extracorp\u00f3rea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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