{"id":78412,"date":"2018-03-09T23:24:02","date_gmt":"2018-03-09T23:24:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-dominio-intracelular-de-tace-adam17-en-la-regulacion-de-su-actividad-catala%c2%adtica\/"},"modified":"2018-03-09T23:24:02","modified_gmt":"2018-03-09T23:24:02","slug":"papel-del-dominio-intracelular-de-tace-adam17-en-la-regulacion-de-su-actividad-catala%c2%adtica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-dominio-intracelular-de-tace-adam17-en-la-regulacion-de-su-actividad-catala%c2%adtica\/","title":{"rendered":"Papel del dominio intracelular de tace\/adam17 en la regulaci\u00f3n de su actividad catal\u00edtica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Villanueva De La Torre Mar\u00eda  Teresa <\/strong><\/h2>\n<p>Un n\u00famero sustancial de prote\u00ednas de transmembrana de la superficie celular sufren un corte proteol\u00edtico que conduce a la liberaci\u00f3n de su dominio extracelular. Este proceso, conocido como \u00abshedding\u00bb, remodela la superficie de las c\u00e9lulas y regula la funci\u00f3n de un n\u00famero diverso de prote\u00ednas de transmembrana que incluyen factores de crecimiento, citoquinas, mol\u00e9culas de adhesi\u00f3n, receptores de factores de crecimiento y de citoquinas. Durante la d\u00e9cada de los ochenta y noventa se puso de manifiesto el papel que jugaban metaloproteasas dependientes de zinc en la realizaci\u00f3n de la mayor\u00eda, si no de todos, los procesos de shedding descritos, ya que inhibidores de metaloproteasas bloquean de forma eficaz este proceso. A\u00f1os m\u00e1s tarde se identific\u00f3 la primera metaloprotease, un miembro de la subfamilia adam, responsable del corte proteol\u00edtico de una prote\u00edna de transmembrana, la citoquina tnf-alpha, por lo que esta proteasa fue denominada adam 17 o tace (tumor necrosis factor-  converting enzyme). El fenotipo de los ratones tace zn\/ zn muestra que tace es esencial en el desarrollo de estos animales y el uso de fibroblastos derivados de ellos demostr\u00f3 que no solo es responsable del shedding de tnf-alpha sino tambi\u00e9n del shedding de un gran n\u00famero de prote\u00ednas de transmembrana de funci\u00f3n y estructuras muy distintas. Dada esta variedad de sustratos, entre ellos ligandos de la familia del egf, es razonable conjeturar que la actividad de tace estar\u00e1 bajo un riguroso control para prevenir la prote\u00f3lisis no deseada y la activaci\u00f3n de determinados receptores. No obstante, se conoce poco acerca de los mecanismos responsables de la regulaci\u00f3n de la actividad de tace. Tace es una prote\u00edna de transmembrana de tipo i (con la regi\u00f3n amino-terminal en la zona extracelular\/intraluminal) que contiene los siguientes dominios identificables: p\u00e9ptido se\u00f1al, prodominio, dominio catal\u00edtico o metaloproteasa, dominio desintegrina, dominio r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del dominio intracelular de tace\/adam17 en la regulaci\u00f3n de su actividad catal\u00edtica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del dominio intracelular de tace\/adam17 en la regulaci\u00f3n de su actividad catal\u00edtica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Villanueva De La Torre Mar\u00eda  Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Arribas Lopez Joaquin Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Ramon y cajal ag\u00ed\u00bceras <\/li>\n<li>anna Messeguer navarro (vocal)<\/li>\n<li>francesc Canals sur\u00eds (vocal)<\/li>\n<li> Gomis ruth f. xavier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Villanueva De La Torre Mar\u00eda Teresa Un n\u00famero sustancial de prote\u00ednas de transmembrana de la superficie celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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