{"id":78487,"date":"2018-03-09T23:24:10","date_gmt":"2018-03-09T23:24:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dosis-unica-de-metronidazol-y-gentamicina-para-profilaxis-antibiotica-en-ciruga%c2%ada-colorrectal\/"},"modified":"2018-03-09T23:24:10","modified_gmt":"2018-03-09T23:24:10","slug":"dosis-unica-de-metronidazol-y-gentamicina-para-profilaxis-antibiotica-en-ciruga%c2%ada-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/dosis-unica-de-metronidazol-y-gentamicina-para-profilaxis-antibiotica-en-ciruga%c2%ada-colorrectal\/","title":{"rendered":"Dosis \u00fanica de metronidazol y gentamicina para profilaxis antibi\u00f3tica en cirugia colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ventura Cerd\u00e1 Jos\u00e9 Manuel <\/strong><\/h2>\n<p>En pacientes sometidos a cirug\u00eda colorrectal programada, la administraci\u00f3n profil\u00e1ctica por v\u00eda intravenosa de una dosis \u00fanica (du) preoperatoria de la mezcla de metronidazol 1500 mg y gentamicina 240 mg, presenta unas caracter\u00edsticas farmacocin\u00e9ticas que garantizan una efectividad y seguridad similar a la administraci\u00f3n de estos mismos antibi\u00f3ticos en dosis m\u00faltiple (dm), acompa\u00f1ada de una reducci\u00f3n de costes directos del tratamiento.  para analizar la verosimilitud de esta hip\u00f3tesis se dise\u00f1a un estudio retrospectivo de cohortes, aprobado por el comit\u00e9 \u00e9tico de investigaci\u00f3n cl\u00ednica del hospital general de castell\u00f3n. La cohorte de casos est\u00e1 constituida por pacientes intervenidos de cirug\u00eda colorrectal programada en el servicio de cirug\u00eda general y digestiva del hospital general de castell\u00f3n que recibieron metronidazol y gentamicina en du preoperatoria entre enero de 1999 y diciembre de 2003. La cohorte de controles la forman los pacientes intervenidos de cirug\u00eda colorrectal programada en esta misma instituci\u00f3n entre enero de 1995 y diciembre de 1997 y que recibieron metronidazol y gentamicina en un esquema profil\u00e1ctico de dm.  para demostrar la hip\u00f3tesis formulada, se han desarrollado los siguientes objetivos:  1. Poner a punto las t\u00e9cnicas anal\u00edticas necesarias para la determinaci\u00f3n de metronidazol y gentamicina en suero humano.  2. Analizar, en un subgrupo de pacientes de la cohorte de casos, las concentraciones s\u00e9ricas de metronidazol y gentamicina y calcular sus par\u00e1metros farmacocin\u00e9ticos.  3. Definir un sistema de identificaci\u00f3n de pacientes sometidos a cirug\u00eda colorrectal y de las complicaciones que puedan haber sufrido, a partir del conjunto m\u00ednimo b\u00e1sico de datos (cmbd).  4. Calcular el riesgo relativo de infecci\u00f3n postquir\u00fargica en la cohorte de casos con relaci\u00f3n a los controles.  5. Determinar y comparar la mortalidad intrahospitalaria en ambas cohortes.  6. Calcular y comp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dosis \u00fanica de metronidazol y gentamicina para profilaxis antibi\u00f3tica en cirugia colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dosis \u00fanica de metronidazol y gentamicina para profilaxis antibi\u00f3tica en cirugia colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ventura Cerd\u00e1 Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Alos Almi\u00f1ana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor Jimenez torres <\/li>\n<li>irene teresa Molina  Martinez (vocal)<\/li>\n<li>Juan  Antonio Barcia albacar (vocal)<\/li>\n<li>Juan  pablo Ordovas baines (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ventura Cerd\u00e1 Jos\u00e9 Manuel En pacientes sometidos a cirug\u00eda colorrectal programada, la administraci\u00f3n profil\u00e1ctica por v\u00eda intravenosa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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