{"id":78488,"date":"2018-03-09T23:24:10","date_gmt":"2018-03-09T23:24:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genomico-y-funcional-de-los-factores-de-transcripcion-e2f1-y-e2f2-en-el-mantenimiento-de-la-homeostasis-pancreatica-y-hematopoyetica\/"},"modified":"2018-03-09T23:24:10","modified_gmt":"2018-03-09T23:24:10","slug":"analisis-genomico-y-funcional-de-los-factores-de-transcripcion-e2f1-y-e2f2-en-el-mantenimiento-de-la-homeostasis-pancreatica-y-hematopoyetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/analisis-genomico-y-funcional-de-los-factores-de-transcripcion-e2f1-y-e2f2-en-el-mantenimiento-de-la-homeostasis-pancreatica-y-hematopoyetica\/","title":{"rendered":"An\u00e1lisis gen\u00f3mico y funcional de los factores de transcripci\u00f3n e2f1 y e2f2 en el mantenimiento de la homeostasis pancre\u00e1tica y hematopoy\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ainhoa Iglesias Ara <\/strong><\/h2>\n<p>Los factores de transcripci\u00f3n de la familia e2f (e2f1-8) son elementos cr\u00edticos en el control del ciclo celular, regulando la expresi\u00f3n de numerosos genes diana implicados en procesos tales como la replicaci\u00f3n del dna, la entrada y progresi\u00f3n en fase s o la apoptosis. Estudios in vivo e in vitro sugieren que cada uno de los miembros de la familia e2f desempe\u00f1a funciones espec\u00edficas en el desarrollo y en la homeostasis del organismo, aunque se desconoce el mecanismo de acci\u00f3n de cada miembro e2f, as\u00ed como un grado de redundancia funcional.     en el presente trabajo se han analizado, mediante estudios gen\u00f3micos y funcionales, las funciones \u00fanicas y compartidas de e2f1 y e2f2, haciendo uso de ratones portando mutaciones inactivadoras para e2f1 y e2f2 o ambos (dko), generados en nuestro laboratorio.     se ha encontrando que e2f1 y e2f2 juegan un papel cr\u00edtico en el mantenimiento de la homeostasis pancre\u00e1tica y hematopoy\u00e9tica, operando a trav\u00e9s de mecanismos similares en ambos sistemas. La inactivaci\u00f3n simult\u00e1nea de e2f1 y e2f2 conduce al desarrollo de la diabetes, la atrofia pancre\u00e1tica postanatal e hipertrofia y displasia de las c\u00e9lulas acinares, todo ello acompa\u00f1ado de una mayor tasa de s\u00edntesis de dna y apoptosis in vivo y de una supresi\u00f3n de los marcadores de diferenciaci\u00f3n pancre\u00e1ticos. Asimismo, el sistema hematopoy\u00e9tico de los ratones dko se caracteriza por la reducida capacidad de los progenitores del linaje monoc\u00edtico de producir macr\u00f3fagos diferenciados. El efecto proliferativo tambi\u00e9n est\u00e1 acompa\u00f1ado en este caso de una mayor tasa de s\u00edntesis de dna y duplicaci\u00f3n de centrosomas seguidos de un bloqueo de la progresi\u00f3n del ciclo y de apoptosis.     el an\u00e1lisis de los perfiles de expresi\u00f3n g\u00e9nica en el p\u00e1ncreas y la m\u00e9dula \u00f3sea indica que la inactivaci\u00f3n simult\u00e1nea de e2f1 y e2f2 funcionan como represores dela proliferaci\u00f3n celular mediante la regulaci\u00f3n negativa de la expresi\u00f3n de estos genes. El incremento im<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis gen\u00f3mico y funcional de los factores de transcripci\u00f3n e2f1 y e2f2 en el mantenimiento de la homeostasis pancre\u00e1tica y hematopoy\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis gen\u00f3mico y funcional de los factores de transcripci\u00f3n e2f1 y e2f2 en el mantenimiento de la homeostasis pancre\u00e1tica y hematopoy\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ainhoa Iglesias Ara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Zubiaga Elordieta Ana M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li> Molina pineda ignacio Jes\u00fas (vocal)<\/li>\n<li>Francisco xavier Real arribas (vocal)<\/li>\n<li>Javier Le\u00f3n serrano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ainhoa Iglesias Ara Los factores de transcripci\u00f3n de la familia e2f (e2f1-8) son elementos cr\u00edticos en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,962,12909],"tags":[168710,13679,14452,14602,168711,36390],"class_list":["post-78488","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-genetica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ainhoa-iglesias-ara","tag-francisco-xavier-real-arribas","tag-javier-leon-serrano","tag-jose-fernandez-piqueras","tag-molina-pineda-ignacio-jesus","tag-zubiaga-elordieta-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78488"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78488\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}