{"id":78504,"date":"2006-02-02T00:00:00","date_gmt":"2006-02-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-telomerica-en-tumores-humanos-implicaciones-pronosticas\/"},"modified":"2006-02-02T00:00:00","modified_gmt":"2006-02-02T00:00:00","slug":"estudio-de-la-funcion-telomerica-en-tumores-humanos-implicaciones-pronosticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-telomerica-en-tumores-humanos-implicaciones-pronosticas\/","title":{"rendered":"Estudio de la funci\u00f3n telom\u00e9rica en tumores humanos. implicaciones pron\u00f3sticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Garc\u00eda-aranda Jimenez <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se ha desarrollado un inter\u00e9s creciente, por parte de investigadores b\u00e1sicos y cl\u00ednicos, para trabajar conjuntamente sobre un tema de una enorme trascendencia social, como es el c\u00e1ncer. Mientras que las cifras sobre la incidencia de c\u00e1ncer son alarmente, estos n\u00fameros oscurecen el hecho de que, a nivel celular, la transformaci\u00f3n maligna es extremadamente rara. en realidad estamos protegidos eficientemente de la tumorig\u00e9nesis por un complejo conjunto de mecanismos de defensa y el desarrollo tumoral s\u00f3lo es posible cuando se inactivan estos mecanismos. A medida que se conocen las rutas a trav\u00e9s de las que se controla la supresi\u00f3n tumoral, se desvelan distintos puntos de regulaci\u00f3n cr\u00edticos que est\u00e1n frecuentemente alterados durante la progresi\u00f3n maligna.     el acortamiento de los tel\u00f3meros y la represi\u00f3n de la telomerasa, en la mayor\u00eda de los tejidos som\u00e1ticos humanos, constituye una importante barrera que nos protege frente al c\u00e1ncer. Por el contrario, la estabilizaci\u00f3n de los tel\u00f3meros, generalmente a trav\u00e9s de la activaci\u00f3n de la telomerasa, es un paso cr\u00edtico para la proliferaci\u00f3n celular indefinida, y, por tanto, para la formaci\u00f3n de tumores. Este hecho ha conducido a un gran inter\u00e9s por identificar la funci\u00f3n de los tel\u00f3meros y la telomerasa en el procesos tumorig\u00e9nico, con el fin \u00faltimo de su utilizaci\u00f3n como dianas terap\u00e9uticas para imitar el crecimiento exponencial de las c\u00e9lulas transformadas. La investigaci\u00f3n de la din\u00e1mica de los tel\u00f3meros nos proporciona una excelente oportunidad para comprender los mecanismos de control de la proliferaci\u00f3n celular.     en esta tesis se ahonda en la comprensi\u00f3n del contexto y los mecanismos por los cuales los tel\u00f3meros y la telomerasa contribuyen al desarrollo de distintos tipos de tumores humanos, como son el c\u00e1ncer colorrectal, el c\u00e1ncer g\u00e1strico y el c\u00e1ncer no microc\u00edtico de pulm\u00f3n. El an\u00e1lisis con fines pron\u00f3sticos de distintos par\u00e1metros de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la funci\u00f3n telom\u00e9rica en tumores humanos. implicaciones pron\u00f3sticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la funci\u00f3n telom\u00e9rica en tumores humanos. implicaciones pron\u00f3sticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Garc\u00eda-aranda Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Iniesta Serrano Mar\u00eda Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  jose Torres Garc\u00eda <\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li> Balsco marhuenda Mar\u00eda antonia (vocal)<\/li>\n<li>Miguel de la Hoya mantec\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Garc\u00eda-aranda Jimenez En los \u00faltimos a\u00f1os se ha desarrollado un inter\u00e9s creciente, por parte de investigadores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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