{"id":78532,"date":"2006-03-02T00:00:00","date_gmt":"2006-03-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-entre-bacterias-lacticas-celulas-del-epitelio-intestinal-y-celulas-del-sistema-inmunitario-desarrollo-de-modelos-in-vitro\/"},"modified":"2006-03-02T00:00:00","modified_gmt":"2006-03-02T00:00:00","slug":"interacciones-entre-bacterias-lacticas-celulas-del-epitelio-intestinal-y-celulas-del-sistema-inmunitario-desarrollo-de-modelos-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/interacciones-entre-bacterias-lacticas-celulas-del-epitelio-intestinal-y-celulas-del-sistema-inmunitario-desarrollo-de-modelos-in-vitro\/","title":{"rendered":"Interacciones entre bacterias l\u00e1cticas, c\u00e9lulas del epitelio intestinal y c\u00e9lulas del sistema inmunitario. desarrollo de modelos in vitro."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Langa Marcano <\/strong><\/h2>\n<p>La leche materna es el alimento ideal paralos reci\u00e9n nacidos ya que satisface todos su requerimientos nutritivos y les protege frente a infecciones. En el momento de iniciarse esta tesis doctoral, los pocos estudios existentes sobre la microbiolog\u00eda de la leche humana se restring\u00edan b\u00e1sicamente al aislamiento e identificaci\u00f3n de bacterias potencialmente pat\u00f3genas en bancos de leche y en casos de mastitis o infecciones neonatales. En consecuencia, se desconoc\u00eda la composici\u00f3n microbiol\u00f3gica de la leche de mujeres sanas.     inicialmente se investig\u00f3 si este fluido biol\u00f3gico conten\u00eda bacterias l\u00e1cticas (bal) y, de hecho, se pudieron aislar de leche, areola mamaria, piel del pecho, vagina y heces de ocho madres sanas y de la cavidad oral y heces de sus respectivos hijos. A continuaci\u00f3n se seleccionaron al azar algunos aislados (178 de cada pareja madre-hijo) y se sometieron a un an\u00e1lisis de sus perfiles gen\u00e9ticos mediante la t\u00e9cnica rapd. Posteriormente, se identificaron aquellos asilados que, independientemente de su origen, compart\u00edan perfiles id\u00e9nticos. Los resultados revelaron que la leche materna es una fuente importante de bal para el intestino neonatal y que las bal presentes en la leche pueden tener un origen end\u00f3geno (el intestino materno).     en este sentido, se estudi\u00f3 la posibilidad de que ciertas bacterias l\u00e1cticas fuesen capaces de atravesar el epitelio intestinal mediante un mecanismo mediado por c\u00e9lulas dendr\u00edticas. Inicialmente se evalu\u00f3 la capacidad de dos cepas aisladas de leche materna, lactobacillus salivarius cect5713 y enterococcus faecium m1a, para provocar la activaci\u00f3n de c\u00e9lulas dendr\u00edtcas inmaduras de origen murino (c\u00e9lulas d1). Para ello, se analiz\u00f3 la expresi\u00f3n de dos marcadores de activaci\u00f3n (mhc-ii y b7.2). Una vez comprobada la capacidad de activaci\u00f3n de ambas cepas, se procedi\u00f3 a la realizaci\u00f3n de estudios de translaci\u00f3n en modelos biocompartimentales tipo transwell utilizando c\u00e9lulas tipo-dend<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones entre bacterias l\u00e1cticas, c\u00e9lulas del epitelio intestinal y c\u00e9lulas del sistema inmunitario. desarrollo de modelos in vitro.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones entre bacterias l\u00e1cticas, c\u00e9lulas del epitelio intestinal y c\u00e9lulas del sistema inmunitario. desarrollo de modelos in vitro. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Langa Marcano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez G\u00f3mez Juan  Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lorenzo De la hoz perales <\/li>\n<li>jordi Xaus pey (vocal)<\/li>\n<li>kamal Ivory (vocal)<\/li>\n<li>pilar Gaya sicilia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Langa Marcano La leche materna es el alimento ideal paralos reci\u00e9n nacidos ya que satisface todos 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