{"id":78539,"date":"2006-03-02T00:00:00","date_gmt":"2006-03-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-silimarina-en-cultivos-celulares-de-silybum-marianum-l-gaerth\/"},"modified":"2006-03-02T00:00:00","modified_gmt":"2006-03-02T00:00:00","slug":"produccion-de-silimarina-en-cultivos-celulares-de-silybum-marianum-l-gaerth","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-vegetal\/produccion-de-silimarina-en-cultivos-celulares-de-silybum-marianum-l-gaerth\/","title":{"rendered":"Produccion de silimarina en cultivos celulares de silybum marianum (l.) gaerth"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Sampedro M\u00aa Angeles <\/strong><\/h2>\n<p>La producci\u00f3n de silimarina, compuesto constitutivo de los frutos de silybum marianum con fuerte actividad hepatoprotectora y antihepatot\u00f3xica, est\u00e1 severamente reducida en cultivos celulares derivados de esta especie.   la adici\u00f3n de precursores biosint\u00e9ticos de la ruta metab\u00f3lica o la modificaci\u00f3n de los niveles de az\u00facares a\u00f1adidos al medio de cultivo no aument\u00f3 la producci\u00f3n en los cultivos celulares. La eliminaci\u00f3n de iones calcio del medio de cultivo, aunque redujo el crecimiento, provoc\u00f3 la acumulaci\u00f3n de silimarina a lo largo del ciclo de cultivo.  la acumulaci\u00f3n de silimarina en cultivos de s. Marianum puede ser inducida por un elicitor bi\u00f3tico de origen f\u00fangico y presumiblemente su actuaci\u00f3n est\u00e1 mediada por la ruta de los octadecanoides. El metil jasmonato act\u00fa\u00f3 en una serie de pasos de la ruta metab\u00f3lica y su efecto fue totalmente dependiente de la s\u00edntesis \u00abde novo\u00bb de prote\u00ednas. La actividad chalcona sintasa aument\u00f3 por la acci\u00f3n de metil jasmonato; sin embargo, no existi\u00f3 una relaci\u00f3n temporal entre la acumulaci\u00f3n de silimarina y el incremento de la actividad enzim\u00e1tica. los cultivos celulares de s. Marianum no parecen utilizar rutas de se\u00f1alizaci\u00f3n t\u00edpicas en la traducci\u00f3n de se\u00f1ales, ya que la elicitaci\u00f3n no fue asociada a un estallido oxidativo, la activaci\u00f3n de las cascadas de fosforilaci\u00f3n y defosforilaci\u00f3n no mediaron en el mecanismo de elicitaci\u00f3n y la disponibilidad de calcio extracelular o la alteraci\u00f3n de flujos citos\u00f3licos no fueron esenciales en la elicitaci\u00f3n. diversas pruebas realizadas \u00abin vivo\u00bb e \u00abin vitro\u00bb revelaron que la biotransformaci\u00f3n de estos compuestos por peroxidasas puede contribuir al mantenimiento de los niveles constitutivos de flavonolignanos detectados en los cultivos aunque estas enzimas no participaron en el mecanismo de elicitaci\u00f3n. los cultivos celulares de s. Marianum experimentan una extensa reprogramaci\u00f3n metab\u00f3lica en respuesta a la elicitaci\u00f3n. El metabolismo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Produccion de silimarina en cultivos celulares de silybum marianum (l.) gaerth<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Produccion de silimarina en cultivos celulares de silybum marianum (l.) gaerth <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Sampedro M\u00aa Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Purificaci\u00f3n Corchete S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rob Verpoorte <\/li>\n<li>angeles Pedre\u00f1o M\u00aa (vocal)<\/li>\n<li>berta Dopico rivela (vocal)<\/li>\n<li>cesar Ruiz perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Sampedro M\u00aa Angeles La producci\u00f3n de silimarina, compuesto constitutivo de los frutos de silybum marianum con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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