{"id":78594,"date":"2006-09-02T00:00:00","date_gmt":"2006-09-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mediadores-moleculares-implicados-en-los-mecanismos-de-regulacion-microambiental-de-la-metastasis-hepatica-experimental-del-cancer-de-colon\/"},"modified":"2006-09-02T00:00:00","modified_gmt":"2006-09-02T00:00:00","slug":"mediadores-moleculares-implicados-en-los-mecanismos-de-regulacion-microambiental-de-la-metastasis-hepatica-experimental-del-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/mediadores-moleculares-implicados-en-los-mecanismos-de-regulacion-microambiental-de-la-metastasis-hepatica-experimental-del-cancer-de-colon\/","title":{"rendered":"Mediadores moleculares implicados en los mecanismos de regulaci\u00f3n microambiental de la met\u00e1stasis hep\u00e1tica experimental del c\u00e1ncer de col\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Solaum Aguirre Miren Sorne <\/strong><\/h2>\n<p>El presente trabajo pretendi\u00f3 investigar la actividad funcional del carcinoma de colon murino 51b durante su interacci\u00f3n con las c\u00e9lulas del endotelio sinusoidal hep\u00e1tico, a factores  proinflamatorios como el lps, as\u00ed como el efecto de un antiangig\u00e9nico natural como es la endostaatina en el desarrollo de la met\u00e1stasis experimental de dicho carcinoma de colon.  los resultados obtenidos en el presente estudio demuestran que el esh estimula al cc-51b aumentando la adhesi\u00f3n, migraci\u00f3n y proliferaci\u00f3n del tumor y que la acci\u00f3n del medio condicionado del esh sobre al cc-21b activa tanto la translocaci\u00f3n nuclear del nfkappa b, como la expresi\u00f3n del tnf-alfa por parte de las c\u00e9lulas del carcinoma del colon. todo ello condujo a que el mc del esh aumentar la met\u00e1stasis hep\u00e1tica producida por el cc-51b. adem\u00e1s, el presente estudio caracteriz\u00f3, la influencia de las endotoxinas bacteriana en la capacidad del cc-51b de producir met\u00e1stasis. El lps activ\u00f3 al cc-51b, uni\u00e9ndose directamente a la c\u00e9lula tumoral, aumentado el desarrollo de la met\u00e1stasis hep\u00e1tica mediante el aumento de adhesi\u00f3n al esh, migraci\u00f3n y proliferaci\u00f3n, estando involucradas mol\u00e9culas de adhesi\u00f3n como vcam-1 o vla-4 sobre expresadas por la acci\u00f3n del lps y el tnf-alfa ya que anticuerpos espec\u00edficos inhib\u00edan el aumento de adhesi\u00f3n producido por el lps. Adem\u00e1s el lps estimulo la producci\u00f3n tumoral de tnf-alfa, v\u00eda nf-kappab, as\u00ed como la expresi\u00f3n de su receptor, actuando como mediador del efecto prometast\u00e1tico del lps, siendo tanto activador del factor de transcripci\u00f3n kappab, como inductor de met\u00e1stasis, puesto que al utilizarlo directamente se comprob\u00f3 que produc\u00eda un aumento significativo de las mismas. El vegf es otro factor que contribuy\u00f3 a la activaci\u00f3n del cc bien de forma directa sobre el tumor o de forma indirecta facilitando la acci\u00f3n del tnf-alfa mediante el aumento de expresi\u00f3n de su receptor.     por \u00faltimo, el an\u00e1lisis del efecto de la endostatina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mediadores moleculares implicados en los mecanismos de regulaci\u00f3n microambiental de la met\u00e1stasis hep\u00e1tica experimental del c\u00e1ncer de col\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mediadores moleculares implicados en los mecanismos de regulaci\u00f3n microambiental de la met\u00e1stasis hep\u00e1tica experimental del c\u00e1ncer de col\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Solaum Aguirre Miren Sorne <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bonifacio nicol\u00e1s Diaz chico <\/li>\n<li>salvador Ali\u00f1o (vocal)<\/li>\n<li>Rafael De llorens duran (vocal)<\/li>\n<li>Ana Alonso varona (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Solaum Aguirre Miren Sorne El presente trabajo pretendi\u00f3 investigar la actividad funcional del carcinoma de colon murino [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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