{"id":78635,"date":"2006-10-02T00:00:00","date_gmt":"2006-10-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/molecular-recognition-of-glycomimetics-by-proteins-a-3d-view-by-using-nmr\/"},"modified":"2006-10-02T00:00:00","modified_gmt":"2006-10-02T00:00:00","slug":"molecular-recognition-of-glycomimetics-by-proteins-a-3d-view-by-using-nmr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-de-los-hidratos-de-carbono\/molecular-recognition-of-glycomimetics-by-proteins-a-3d-view-by-using-nmr\/","title":{"rendered":"Molecular recognition of glycomimetics by proteins. a 3d view by using nmr"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Mari <\/strong><\/h2>\n<p>Durante los \u00faltimos a\u00f1os se ha demostrado que los carbohidratos est\u00e1n ampliamente distribuido por la naturaleza y que desempe\u00f1an un elevado n\u00famero de funciones biol\u00f3gicas. hoy en d\u00eda est\u00e1 claro que el principal papel biol\u00f3gico de los carbohidratos es el de ser puntos espec\u00edficos de reconocimiento molecular para lectinas, toxinas, enzimas y anticuerpos. De hecho los procesos de reconocimiento molecular carbohidrato\/proteina intervienen en el plegamiento y maduraci\u00f3n de las glicoprote\u00ednas, en la adhesi\u00f3n celular, en el control de crecimiento celular y en otras actividades celulares, como la embriog\u00e9nesis. desde una perspectiva general, es obvio que para que el proceso de reconocimiento molecular tenga lugar, las estructuras tridimensionales del carbohidrato y del receptor juegan un papel primordial. Desde un punto de vista racional, y considerando los carbohidratos (o sus an\u00e1logos sint\u00e9ticos: glicomim\u00e9ticos) como posibles f\u00e1rmacos, est\u00e1 claro que un conocimiento de sus estructura tanto en estado libre como asociado a su receptor es importante. el conocimiento de la estructura tridimensional del carbohidrato en disoluci\u00f3n s\u00f3lo puede obtenerse mediante t\u00e9cnicas de  resonancia magn\u00e9ticas nuclear (rmn). En caso favorables, el uso de rmn tambi\u00e9n puede permitir la determinaci\u00f3n estructural completa de prote\u00ednas libres o de complejo prote\u00edna-carbohidrato. Sin embargo, se sabe que esta t\u00e9cnica experimental impone serios l\u00edmites en los relativo al tama\u00f1o del sistema. \u00e9ste l\u00edmite est\u00e1 en torno a 100 residuos para prote\u00ednas sin marcaje siot\u00f3pico, a 150 para aquellas etiquetadas con 15n  y en torno a 300 para las doblemente (15n, 13c) marcadas. Sin embargo, a\u00fan en los caos en que el tama\u00f1o del sistema es demasiado grande para conseguir una determinaci\u00f3n estructural completa, la rmn puede, en caso favorables, ofrecer informaci\u00f3n sobre la conformaci\u00f3n del ligando en el centro de reconocimiento de la prote\u00edna; es decir, sobre la posible c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Molecular recognition of glycomimetics by proteins. a 3d view by using nmr<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Molecular recognition of glycomimetics by proteins. a 3d view by using nmr <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Mari <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>barbero Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Carretero gonz\u00e1lvez <\/li>\n<li> Camarasa ruis Mar\u00eda Jos\u00e9 (vocal)<\/li>\n<li>nazario Martin leon (vocal)<\/li>\n<li>sergio Castillon miranda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Mari Durante los \u00faltimos a\u00f1os se ha demostrado que los carbohidratos est\u00e1n ampliamente distribuido por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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