{"id":78694,"date":"2018-03-09T23:24:23","date_gmt":"2018-03-09T23:24:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-ontogenica-e-implicaciones-fisiopatologicas-y-diagnosticas-de-los-cambios-en-la-sa%c2%adntesis-hepatica-de-acidos-biliares\/"},"modified":"2018-03-09T23:24:23","modified_gmt":"2018-03-09T23:24:23","slug":"evolucion-ontogenica-e-implicaciones-fisiopatologicas-y-diagnosticas-de-los-cambios-en-la-sa%c2%adntesis-hepatica-de-acidos-biliares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-experimental\/evolucion-ontogenica-e-implicaciones-fisiopatologicas-y-diagnosticas-de-los-cambios-en-la-sa%c2%adntesis-hepatica-de-acidos-biliares\/","title":{"rendered":"Evoluci\u00f3n ontog\u00e9nica e implicaciones fisiopatol\u00f3gicas y diagn\u00f3sticas de los cambios en la s\u00edntesis hep\u00e1tica de \u00e1cidos biliares."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Cuesta De Juan <\/strong><\/h2>\n<p>Se han investigado los cambios ontog\u00e9nicos, en la rata, del pool de \u00e1cidos biliares (abs) -analizado mediante t\u00e9cnicas enzim\u00e1ticas y gc-ms-, y de la expresi\u00f3n de enzimas (cyp7a1, cyp8b1, cyp27, cyp3a11, 5\u00c2\u00bfreductasa y 5\u00edYreductasa), transportadores (bsep, ntcp, asbt y ost\u00c2\u00bf\/ost\u00edY) y receptores nucleares (ftf, fxr, shp y hnf4\u00c2\u00bf) implicados en su homeostasis, utilizando pcr cuantitativa y an\u00e1lisis de western blot. El tama\u00f1o absoluto del pool de abs aument\u00f3 progresivamente hasta la edad adulta. La complejidad de su composici\u00f3n, que era alta el fetos, disminuy\u00f3 tras en nacimiento y aument\u00f3 despu\u00e9s progresivamente hasta la edad adulta, para volver a disminuir en animales senescentes. S\u00f3lo apareci\u00f3 \u00e1cido allo-c\u00f3lico en el desarrollo temprano, a pesar de la baja expresi\u00f3n de 5\u00c2\u00bf -reductasa. El tama\u00f1o relativo del pool de abs, corregido por peso hep\u00e1tico, se mantuvo constante desde la primera semana de vida hasta la senescencia, excepto tras el destete, cuando se detect\u00f3 un aumento transitorio, acompa\u00f1ado de una disminuci\u00f3n de la expresi\u00f3n de shp y un aumento de la de cyp7a1. El retraso del momento del destete una semana no afect\u00f3 al tama\u00f1o del pool de abs, pero disminuy\u00f3 la proporci\u00f3n de \u00e1cido quenodesoxic\u00f3lico y \u00c2\u00bf-muric\u00f3lico, y aument\u00f3 la de \u00e1cido c\u00f3lico, probablemente debido a una mayor expresi\u00f3n de cyp8b1. En conjunto, los cambios en la expresi\u00f3n de genes implicados en la homeostasis de los abs podr\u00edan jugar un papel en la adaptaci\u00f3n fisiol\u00f3gica de la funci\u00f3n digestiva durante el desarrollo. Por otra parte, se investig\u00f3 tambi\u00e9n la expresi\u00f3n hep\u00e1tica de prote\u00ednas implicadas en la s\u00edntesis y transporte de oxisteroles en el rat\u00f3n ob\/ob, encontr\u00e1ndose una marcada disminuci\u00f3n para todos los genes analizados, que no se revertia por tratamiento con rosiglitazona. Esto indica que en los ratones ob\/ob est\u00e1 alterada la homeostasis de los oxisteroles y la funci\u00f3n hepatobiliar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evoluci\u00f3n ontog\u00e9nica e implicaciones fisiopatol\u00f3gicas y diagn\u00f3sticas de los cambios en la s\u00edntesis hep\u00e1tica de \u00e1cidos biliares.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evoluci\u00f3n ontog\u00e9nica e implicaciones fisiopatol\u00f3gicas y diagn\u00f3sticas de los cambios en la s\u00edntesis hep\u00e1tica de \u00e1cidos biliares. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Cuesta De Juan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Jes\u00fas Tu\u00f1\u00f3n gonz\u00e1lez <\/li>\n<li>josefina Mar\u00eda Illera del portal (vocal)<\/li>\n<li>felipe alfonso Jimenez vicente (vocal)<\/li>\n<li>Mar\u00eda Isidoro garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Cuesta De Juan Se han investigado los cambios ontog\u00e9nicos, en la rata, del pool de \u00e1cidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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