{"id":78721,"date":"2018-03-09T23:24:27","date_gmt":"2018-03-09T23:24:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bioactividad-y-metabolismo-de-polifenoles-de-la-dieta-y-sus-metabolitos-en-la%c2%adneas-celulares-humanas-efectos-anticancera%c2%adgenos-y-estrogenicos\/"},"modified":"2018-03-09T23:24:27","modified_gmt":"2018-03-09T23:24:27","slug":"bioactividad-y-metabolismo-de-polifenoles-de-la-dieta-y-sus-metabolitos-en-la%c2%adneas-celulares-humanas-efectos-anticancera%c2%adgenos-y-estrogenicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/bioactividad-y-metabolismo-de-polifenoles-de-la-dieta-y-sus-metabolitos-en-la%c2%adneas-celulares-humanas-efectos-anticancera%c2%adgenos-y-estrogenicos\/","title":{"rendered":"Bioactividad y metabolismo de polifenoles de la dieta y sus metabolitos en l\u00edneas celulares humanas efectos anticancer\u00edgenos y estrog\u00e9nicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Mar Larrosa P\u00e9rez <\/strong><\/h2>\n<p>La tesis aborda el estudio de la actividad biol\u00f3gica y el metabolismo de polifenoles de la dieta. Los polifenoles son metabolitos secundarios de las plantas que se encuentran en la parte a\u00e9rea y frutos, y por tanto forman parte de nuestra dieta. El estudio ha sido llevado a cabo en l\u00edneas celulares humanas de melanoma (sk-mel-28), ademnocarcinoma de colon (caco-2), adenocarcinoma de mama (mcf-7) y colon normal (ccd-112con).  adem\u00e1s, se ha estudiado la actividad biol\u00f3gica de mataboitos derivados del consumo in vivo de alimentos que contienen un determinado tipo de polifenoles, los elagitannos. Para llevar a cabo este trabajo las principales t\u00e9cnicas empleadas han sido,western-blot para an\u00e1lisis de expresi\u00f3n proteica, citometr\u00eda de flujo para estudios del ciclo celular y hplc-ms-ms para los estudios de metabolismo. Los resutados obtenidos muestran que determinados polifenoles de la dieta son capaces de inducir apoptosis en l\u00edneas celaleeres cancerosas humanas y no en l\u00edneas celulares humanas normales por humanas normales por lo que se les podr\u00eda atribuir un efecto anticancer\u00edgeno. El efecto apopt\u00f3tico fue acompa\u00f1ado por una disminuci\u00f3n de la proliferaci\u00f3n y una detenci\u00f3n del cilo. El estudio en profundidad de este apopt\u00f3tico nos llev\u00f3 a determinar que este se produc\u00eda por la v\u00eda intr\u00ednseca o mitocondrial. el estudio de la actividad biol\u00f3gica de los metabolistos generados in vivo por el alimentos ricos en elagitaninos nos llev\u00f3 a descubrir una posible estrog\u00e9nica\/antiestrog\u00e9nica de estos metabolitos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bioactividad y metabolismo de polifenoles de la dieta y sus metabolitos en l\u00edneas celulares humanas efectos anticancer\u00edgenos y estrog\u00e9nicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bioactividad y metabolismo de polifenoles de la dieta y sus metabolitos en l\u00edneas celulares humanas efectos anticancer\u00edgenos y estrog\u00e9nicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Mar Larrosa P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Espin De Gea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garcia conesa Mar\u00eda  teresa (secretario) <\/li>\n<li>laura Bravo clemente (vocal)<\/li>\n<li>Javier Saez valero (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Mar Larrosa P\u00e9rez La tesis aborda el estudio de la actividad biol\u00f3gica y el metabolismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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