{"id":78723,"date":"2018-03-09T23:24:27","date_gmt":"2018-03-09T23:24:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significacion-cla%c2%adnica-de-los-niveles-sericos-preoperatorios-del-antigeno-carbhohidrato-15-3-ca-15-3\/"},"modified":"2018-03-09T23:24:27","modified_gmt":"2018-03-09T23:24:27","slug":"significacion-cla%c2%adnica-de-los-niveles-sericos-preoperatorios-del-antigeno-carbhohidrato-15-3-ca-15-3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significacion-cla%c2%adnica-de-los-niveles-sericos-preoperatorios-del-antigeno-carbhohidrato-15-3-ca-15-3\/","title":{"rendered":"Significaci\u00f3n cl\u00ednica de los niveles sericos preoperatorios del antigeno carbhohidrato 15.3 (ca 15.3)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aranzazu Martin Suarez <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivos  el ca 15.3 es uno de los marcadores tumorales m\u00e1s ampliamente utilizados en el c\u00e1ncer de mama. El prop\u00f3sito de este trabajo fue evaluar pron\u00f3stico de este marcador en pacientes  con esta enfermedad.  material y m\u00e9todos  el estudio incluy\u00f3 un total de 818 mujeres diagnosticadas de c\u00e1ncer de mama invasivo. Determinamos los niveles s\u00e9ricos del marcador por m\u00e9todo inmunoradiom\u00e9trico basado en el principio del \u00abs\u00e1ndwich\u00bb, en el momento del diagn\u00f3stico inicial y antes de cualquier tipo de intervenci\u00f3n quir\u00fargica.  resultados  los niveles s\u00e9ricos preoperatorios del ant\u00edgeno variaron ampliamente, desde 0,9 a 9279 u\/ml. Los niveles normales del marcador (menor 30 u\/ml), se encontraron en un 16,2% de los pacientes. El an\u00e1lisis estad\u00edstico demostr\u00f3 que los niveles s\u00e9ricos preoperatorios del marcador eran significativamente m\u00e1s elevados en pacientes con tumores de mayor tama\u00f1o (t3 o t4), que en aquellos que presentaban tumores de tama\u00f1o m\u00e1s peque\u00f1o (t1 o t2) (p=0,0001). de la misma manera, los niveles s\u00e9ricos del ca 15.3 eran m\u00e1s elevados en pacientes con afectaci\u00f3n ganglionar positiva, que en aquellos sin afectaci\u00f3n axilar (p=0,0001). El an\u00e1lisis univariante demostr\u00f3 que los niveles s\u00e9ricos elevados del marcador (mayor 30u\/ml) se asociaron con un tiempo libre de enfermedad y menor supervivencia global en el total de las pacientes (p=0,0001 y p=0,004, respectivamente), as\u00ed como en el subgrupo de pacientes con afectaci\u00f3n ganglionar positiva (p=0,001 y p=0,03, respectivamente). Por otra parte, el an\u00e1lisis multivariante demostr\u00f3 que los niveles preoperatorios del ant\u00edgeno estuvieron significativa e independientemente asociados con el tiempo libre de enfermedad y la supervivencia en el total de las pacientes, as\u00ed como en el grupo de las pacientes con afectaci\u00f3n ganglionar positiva (p=0,02 para ambos casos).  conclusiones  los resultados demuestran que los niveles elevados del marca<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significaci\u00f3n cl\u00ednica de los niveles sericos preoperatorios del antigeno carbhohidrato 15.3 (ca 15.3)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significaci\u00f3n cl\u00ednica de los niveles sericos preoperatorios del antigeno carbhohidrato 15.3 (ca 15.3) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aranzazu Martin Suarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Garcia Moran Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Martinez rodr\u00edguez <\/li>\n<li>Mar\u00eda  del mar Abad hernandez (vocal)<\/li>\n<li>Manuel Fueyo silva (vocal)<\/li>\n<li>Jos\u00e9 Schneider fontan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aranzazu Martin Suarez Introducci\u00f3n y objetivos el ca 15.3 es uno de los marcadores tumorales m\u00e1s ampliamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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