{"id":78726,"date":"2018-03-09T23:24:27","date_gmt":"2018-03-09T23:24:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-los-factores-de-transcripcion-atf2-y-c-jun-por-la-quinasa-humana-vrk1\/"},"modified":"2018-03-09T23:24:27","modified_gmt":"2018-03-09T23:24:27","slug":"regulacion-de-los-factores-de-transcripcion-atf2-y-c-jun-por-la-quinasa-humana-vrk1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/regulacion-de-los-factores-de-transcripcion-atf2-y-c-jun-por-la-quinasa-humana-vrk1\/","title":{"rendered":"Regulacion de los factores de transcripcion atf2 y c-jun por la quinasa humana vrk1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Sevilla Hernandez <\/strong><\/h2>\n<p>La familia de quinasas vrk  presenta una notable homolog\u00eda con la quinasa b1r del virus vaccinia, esencial para la replicaci\u00f3n del adn viral. Dicha  familia se compone de tres miembros vrk1,vrk2 y vrk3. Vrk1 es capaz de fosforilar diversos factores de transcripci\u00f3n relacionados con respuesta a estr\u00e9s celular como son p53, c-jun y atf2. En el presente trabajo abordamos la  caracterizaci\u00f3n de la fosforilaci\u00f3n de atf2 y c-jun por la quinasa vrk1, as\u00ed como su funci\u00f3n fisiol\u00f3gica en la c\u00e9lula.  vrk1 fosforila a atf2 en los residuos de thr73 y ser62 estabilizando la prote\u00edna y activando su actividad transcripcional.  Tambi\u00e9n hemos podido observar que vrk1 es capaz de activar de forma dosis dependiente el gen de la colagenasa cuya activaci\u00f3n depende de sitios de uni\u00f3n para atf-2. Adem\u00e1s, vrk1 y jnk a dosis sub\u00f3ptimas presentan un efecto aditivo en la actividad transcripcional de atf2. Es por ello que atf2  puede integrar diferentes se\u00f1ales de estr\u00e9s celular mediadas por quinasas diferentes. vrk1 tambi\u00e9n fosforila a c-jun induciendo la estabilidad y la acumulaci\u00f3n de la prote\u00edna. Vrk1 activa la transcripci\u00f3n dependiente de c-jun, la cual depende de la fosforilaci\u00f3n de los residuos de ser63 y ser73. Tanto vrk1 como jnk presentan un efecto aditivo en la activaci\u00f3n transcripcional de c-jun indicando una posible cooperaci\u00f3n entre ambas quinasas. por tanto podemos concluir que la quinasa humana vrk1 (vaccinia-related kinase1) coopera con jnk  tanto en la regulaci\u00f3n de la actividad transcripcional de atf2 como de c-jun. Y ambos factores juegan un papel importante en la supervivencia celular ya que activan la expresi\u00f3n de genes implicados en procesos de reparaci\u00f3n de da\u00f1o al adn  adem\u00e1s de genes que permiten la re-entrada y progresi\u00f3n de las c\u00e9lulas en ciclo celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de los factores de transcripcion atf2 y c-jun por la quinasa humana vrk1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de los factores de transcripcion atf2 y c-jun por la quinasa humana vrk1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Sevilla Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>zbikowski Taracena Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lisardo Bosc\u00e1 gomar <\/li>\n<li>ramiro Barcia vieitez (vocal)<\/li>\n<li>rosario Perona abellon (vocal)<\/li>\n<li>carme Caelles franch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Sevilla Hernandez La familia de quinasas vrk presenta una notable homolog\u00eda con la quinasa b1r del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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