{"id":78739,"date":"2018-03-09T23:24:27","date_gmt":"2018-03-09T23:24:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/derivados-de-sulfamidas-ca%c2%adclicas-y-lineales-como-cannabinoides-y-ligandos-pparalpha\/"},"modified":"2018-03-09T23:24:27","modified_gmt":"2018-03-09T23:24:27","slug":"derivados-de-sulfamidas-ca%c2%adclicas-y-lineales-como-cannabinoides-y-ligandos-pparalpha","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/derivados-de-sulfamidas-ca%c2%adclicas-y-lineales-como-cannabinoides-y-ligandos-pparalpha\/","title":{"rendered":"Derivados de sulfamidas c\u00edclicas y lineales como cannabinoides y ligandos pparalpha"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Cano Ramos <\/strong><\/h2>\n<p>En esta tesis se describe el dise\u00f1o y s\u00edntesis de nuevos derivados heteroc\u00edclicos y lineales que contienen el agrupamiento sulfamida (nr2-so2-nr2), como potenciales cannabinoides y como ligandos del receptor ppara. Se han preparado carboxilatos y carboxamidas de 1,1-dioxo-1,2,6-tiadiazina y se han evaluado como potenciales cannabinoides, encontr\u00e1ndose que modulan la actividad del sistema cannabinoide y pueden comportarse como agonistas, antagonistas o agonistas inversos cannabinoides dependiendo de los sustituyentes del sistema heteroc\u00edclico 1,1-dioxo-1,2-dihidro-1?6-1,2,6-tiadiazina. Por otra parte, se han preparado una nueva clase de derivados de sulfamida de cadena alqu\u00edlica larga, como an\u00e1logos de aciletanolamidas que han mostrado afinidad selectiva por el receptor nuclear ppara, capaces de modular acciones reguladas por estos receptores, en concreto la inducci\u00f3n de saciedad y el control de la ingesta, la reducci\u00f3n de la masa corporal y la regulaci\u00f3n del metabolismo lip\u00eddico.  considerando la familia de carboxilatos y carboxamidas de 1,1-dioxo-1,2,6-tiadiazina, se han puesto a punto los m\u00e9todos sint\u00e9ticos para la preparaci\u00f3n de los 5-carboxilatos y 3-carboxilatos de 1,1-dioxo-1,2,6-tiadiazina, a partir de dos rutas de gran utilidad pr\u00e1ctica. Se ha llevado a cabo la preparaci\u00f3n de 5-carboxilatos de 1,1-dioxo-1,2,6-tiadiazina a partir de 2,4-dioxo\u00e9steres y sulfamidas n-sustituidas. Por otra parte, se obtuvieron los n-bencilderivados de 3-carboxilato de 1,1-dioxo-1,2,6-tiadiazina por reacci\u00f3n de sulfamida y 2,4-dioxo\u00e9steres y posterior n-bencilaci\u00f3n. En la obtenci\u00f3n de las carboxamidas hay que destacar la utilizaci\u00f3n de condiciones de transamidaci\u00f3n muy efectivas en las que el \u00e9ster se transforma directamente en amida, partiendo de carboxilatos de 1,1-dioxo-1,2,6-tiadiazina con diferentes hidrazinas y aminas en presencia de trimetilaluminio.  la evaluaci\u00f3n farmacol\u00f3gica de los nuevos compuestos como potenciales<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Derivados de sulfamidas c\u00edclicas y lineales como cannabinoides y ligandos pparalpha<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Derivados de sulfamidas c\u00edclicas y lineales como cannabinoides y ligandos pparalpha <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Cano Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Goya Laza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Elguero bertolini <\/li>\n<li>Fernando Rodriguez de fonseca (vocal)<\/li>\n<li> Ochoa de oc\u00e1riz herrero carmen (vocal)<\/li>\n<li> Quiroga feijoo Mar\u00eda  luz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Cano Ramos En esta tesis se describe el dise\u00f1o y s\u00edntesis de nuevos derivados heteroc\u00edclicos y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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