{"id":78754,"date":"2018-03-09T23:24:27","date_gmt":"2018-03-09T23:24:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dendra%c2%admeros-de-estructura-carbosilano-solubles-en-agua-sa%c2%adntesis-caracterizacion-y-aplicaciones-biomedicas\/"},"modified":"2018-03-09T23:24:27","modified_gmt":"2018-03-09T23:24:27","slug":"dendra%c2%admeros-de-estructura-carbosilano-solubles-en-agua-sa%c2%adntesis-caracterizacion-y-aplicaciones-biomedicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-organometalicos\/dendra%c2%admeros-de-estructura-carbosilano-solubles-en-agua-sa%c2%adntesis-caracterizacion-y-aplicaciones-biomedicas\/","title":{"rendered":"Dendr\u00edmeros de estructura carbosilano solubles en agua: s\u00edntesis, caracterizaci\u00f3n y aplicaciones biom\u00e9dicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Ortega L\u00f3pez <\/strong><\/h2>\n<p>La tesis titulada \u00abdendr\u00edmeros de naturaleza carbosilano solubles en agua: s\u00edntesis, caracterizaci\u00f3n estructural y aplicaciones biom\u00e9dicas\u00bb desarrolla la s\u00edntesis de macrom\u00e9culas dendr\u00edticas de estructura carbosilano de primera, segunda y tercera generaci\u00f3n con grupos amino y amonio terminales. Los dendr\u00edmeros sintetizados han sido caracterizados mediante an\u00e1lisis elemental de c, h y n y resonancia magn\u00e9tica nuclear de 1h, 13c y 29si. La realizaci\u00f3n adicional de experimentos de rmn bidimensionales ha permitido la asignaci\u00f3n completa de todas las se\u00f1ales. los dendr\u00edmeros de naturaleza carbosilano cati\u00f3nicos han demostrado ser biocompatibles con c\u00e9lulas mononucleares de sangre perif\u00e9rica (cmsp) y hemat\u00edes en un rango de concentraci\u00f3n 1-5 mim. Todos ellos forman complejos de naturaleza electrost\u00e1tica con adn (oligonucle\u00f3tidos fosforotioato y pl\u00e1smidos), con un perfil de biocompatibilidad adedcuado para cmsp y hemat\u00edes. Se ha evaluado la estabilidad de los complejos formados en funci\u00f3n del tiempo, del ph y de la interacci\u00f3n con las prote\u00ednas plasm\u00e1ticas. Los resultados demuestran que estos sistemas son adecuados para su uso en liberaci\u00f3n controlada de mol\u00e9culas bioactivas, adem\u00e1s al proteger el material g\u00e9nico de la interacci\u00f3n con las prote\u00ednas del plasma, implicar\u00eda una administraci\u00f3n de dosis menores para obtener el efecto cl\u00ednico deseado. por \u00faltimo, se han evaluado las posibles aplicaciones biom\u00e9dicas de estos sistemas, estudi\u00e1ndose en particular su uso como veh\u00edculos de transporte, de naturaleza viral, de oligonucle\u00f3tidos antisentido del vih en procesos de transfecci\u00f3n (terapia g\u00e9nica). Los resultados presentados en este trabajo abren la puerta a la utilizaci\u00f3n de macromol\u00e9culas dendr\u00edticas de naturaleza carbosilano en diversas aplicaciones biom\u00e9dicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dendr\u00edmeros de estructura carbosilano solubles en agua: s\u00edntesis, caracterizaci\u00f3n y aplicaciones biom\u00e9dicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dendr\u00edmeros de estructura carbosilano solubles en agua: s\u00edntesis, caracterizaci\u00f3n y aplicaciones biom\u00e9dicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Ortega L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael G\u00f3mez Ram\u00edrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Vallet reg\u00ed <\/li>\n<li>rosa Fandos par\u00eds (vocal)<\/li>\n<li>m. angeles Mu\u00f1oz fernandez (vocal)<\/li>\n<li>beatriz Alonso garrido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Ortega L\u00f3pez La tesis titulada \u00abdendr\u00edmeros de naturaleza carbosilano solubles en agua: s\u00edntesis, caracterizaci\u00f3n estructural y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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