{"id":78782,"date":"2018-03-09T23:24:31","date_gmt":"2018-03-09T23:24:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-receptor-2-del-factor-de-crecimiento-del-endotelio-vascular-vegfr2-y-de-su-valor-pronostico-en-el-osteosarcoma\/"},"modified":"2018-03-09T23:24:31","modified_gmt":"2018-03-09T23:24:31","slug":"estudio-de-la-expresion-del-receptor-2-del-factor-de-crecimiento-del-endotelio-vascular-vegfr2-y-de-su-valor-pronostico-en-el-osteosarcoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-receptor-2-del-factor-de-crecimiento-del-endotelio-vascular-vegfr2-y-de-su-valor-pronostico-en-el-osteosarcoma\/","title":{"rendered":"Estudio de la expresi\u00f3n del receptor 2 del factor de crecimiento del endotelio vascular (vegfr2) y de su valor pron\u00f3stico en el osteosarcoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Gonzalez Billalabeitia <\/strong><\/h2>\n<p>El osteosarcoma es el tumor \u00f3seo maligno m\u00e1s frecuente. La incidencia global estimada es de 2.1 casos por mill\u00f3n de habitantes a\u00f1o. La angiog\u00e9nesis tumoral est\u00e1 implicada en le crecimiento y metastatizaci\u00f3n de m\u00faltiples tumores. La expresi\u00f3n del receptor 2 del factor de crecimiento del endotelio vascular (vegfr2) ha demostrado tener valor pron\u00f3stico en m\u00faltiples tumores. En este trabajo analizamos los resultados cl\u00ednicos de todos los pacientes diagnosticados y\/o tratados de osteossarcoma en los servicios de oncolog\u00eda y pediatr\u00eda en el hospital \u00ab12 de octubre\u00bb de Madrid desde el a\u00f1o 1977 hasta el a\u00f1o 2003, estudiamos la expresi\u00f3n del vegfr2 en las c\u00e9lulas de osteosarcoma en todas las muestras disponibles en el archivo de anatom\u00eda patol\u00f3gica, al diagn\u00f3stico, tras la quimioterapia y en la reca\u00edda , y estudiamos el valor pron\u00f3stico de la densidad microvascular y su correlaci\u00f3n con la expresi\u00f3n del vegfr2.     la serie cl\u00ednica estudiada es representativa de la epidemiolog\u00eda, tratamientos m\u00e9dicos y evoluci\u00f3n del osteosarcoma en el mundo occidental. estudiamos 90 pacientes, con una mediana de edad al diagn\u00f3stico de 15 a\u00f1os. Los principales factores pron\u00f3sticos son la presencia de met\u00e1stasis al diagnostico, la elevaci\u00f3n del ldh, la localizaci\u00f3n proximal y la ausencia de   respuesta al a quimioterapia neoadyuvante. Vegfr2 est\u00e1 expresado en las c\u00e9lulas del osteosarcoma, y esta expresi\u00f3n es detectable mediante inmunohistoqu\u00edma. La expresi\u00f3n de vegfr2 se asocia con una mejor respuesta a la quimioterapia, y un mejor pronostico. Su expresi\u00f3n en la muestra posquimioterapia y en las met\u00e1stasis carece de valor pron\u00f3stico. La densidad microvascular carece de valor predictor de respuesta y de valor pron\u00f3stico. La dmv se correlaciona con la expresi\u00f3n de vegfr2 en la muestra diagn\u00f3stica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n del receptor 2 del factor de crecimiento del endotelio vascular (vegfr2) y de su valor pron\u00f3stico en el osteosarcoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n del receptor 2 del factor de crecimiento del endotelio vascular (vegfr2) y de su valor pron\u00f3stico en el osteosarcoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Gonzalez Billalabeitia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Hitt<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel del Palacio p\u00e9rez-medel <\/li>\n<li>angel Gonz\u00e1lez bar\u00f3n (vocal)<\/li>\n<li>vicente Vicente Garc\u00eda (vocal)<\/li>\n<li>eduardo Ortiz cruz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Gonzalez Billalabeitia El osteosarcoma es el tumor \u00f3seo maligno m\u00e1s frecuente. La incidencia global estimada es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[5309,169260,169261,169258,169259,8242],"class_list":["post-78782","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-angel-del-palacio-perez-medel","tag-angel-gonzalez-baron","tag-eduardo-ortiz-cruz","tag-enrique-gonzalez-billalabeitia","tag-ricardo-hitt","tag-vicente-vicente-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=78782"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/78782\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=78782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=78782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=78782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}