{"id":78799,"date":"2018-03-09T23:24:31","date_gmt":"2018-03-09T23:24:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celulas-dendra%c2%adticas-diferenciadas-in-vitro-con-flt3-l-caracterizacion-fenota%c2%adpica-y-funcional-y-aplicacion-en-terapia-antitumoral\/"},"modified":"2018-03-09T23:24:31","modified_gmt":"2018-03-09T23:24:31","slug":"celulas-dendra%c2%adticas-diferenciadas-in-vitro-con-flt3-l-caracterizacion-fenota%c2%adpica-y-funcional-y-aplicacion-en-terapia-antitumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celulas-dendra%c2%adticas-diferenciadas-in-vitro-con-flt3-l-caracterizacion-fenota%c2%adpica-y-funcional-y-aplicacion-en-terapia-antitumoral\/","title":{"rendered":"C\u00e9lulas dendr\u00edticas diferenciadas in vitro con flt3-l: caracterizaci\u00f3n fenot\u00edpica y funcional y aplicaci\u00f3n en terapia antitumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ver\u00f3nica Parrillas Horche <\/strong><\/h2>\n<p>El trabajo de tesis doctoral, se basa en el an\u00e1lisis de las c\u00e9lulas dendr\u00edticas de rat\u00f3n que se obtienen por diferenciaci\u00f3n in vitro tras cultivo de precursores de m\u00e9dula \u00f3sea con el factor de crecimiento flt3-l (que ser\u00e1n referidas como dcs-flt3-l, en relaci\u00f3n con las c\u00e9lulas dendr\u00edticas obtenidas por diferenciaci\u00f3n in vitro de una manera est\u00e1ndar mediante el cultivo de precursores de m\u00e9dula \u00f3sea con las citoquinas gm-csf e il-4 (que ser\u00e1n referidas como dcs-gm-csf+il-4). El siguiente implic\u00f3 el an\u00e1lisis de las caracter\u00edsticas fenot\u00edpicas y funcionales (en t\u00e9rminos de capacidad de captura de ant\u00edgenos, de estimulaci\u00f3n de linfocitos t y de producci\u00f3n de citoquinas importantes en la inducci\u00f3n de respuestas inmunitarias innatas o adaptativas por las dcs, como il-12 e il-10), por las dcs-flt3 en relaci\u00f3n con las dcs-gm-csf+il-4.  resultados     los resultados obtenidos en este sentido resultan de gran importancia dado que indicaron que a pesar del uso generalizado de las dcs-gm-csf+il-4, tanto para le estudio b\u00e1sico as\u00ed como para las aplicaciones terap\u00e9uticas del as dcs, las dcs-flt3-l representan una poblaci\u00f3n de dcs m\u00e1s representativas de las poblaciones encontradas en los \u00f3rganos linfoides de rat\u00f3n en condiciones fisiol\u00f3gicas que las dcs-gm-csf+il-4. As\u00ed, mientras que en los cultivos de dcs-flt3-l se generan las 3 subpoblaciones de dcs mayoritariamente encontradas en los tejidos linfoides de rat\u00f3n: dcs cd8alfa+, dcs cd8 alfa &#8211; y plasmacitoides (pdcs), en los cultivos de dcs-gm-csf+il-4 s\u00f3lo se genera una poblaci\u00f3n homog\u00e9nea de dcs cd8alfa que, adem\u00e1s, difieren de la subpoblaci\u00f3n de dcs dc8alfa, encontradas in vivo en los tejidos linfoides de rat\u00f3n. adem\u00e1s, las dcs-flt3-l presentaron caracter\u00edsticas de dcs semimaduras, con capacidad de estimulaci\u00f3n de linfocitos t v\u00edrgenes en ausencia de tratamientos con agentes madurativos de dcs y produc\u00edan il-10, en ausencia de tratamiento con agentes madurativos, e il-12, tras t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>C\u00e9lulas dendr\u00edticas diferenciadas in vitro con flt3-l: caracterizaci\u00f3n fenot\u00edpica y funcional y aplicaci\u00f3n en terapia antitumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 C\u00e9lulas dendr\u00edticas diferenciadas in vitro con flt3-l: caracterizaci\u00f3n fenot\u00edpica y funcional y aplicaci\u00f3n en terapia antitumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ver\u00f3nica Parrillas Horche <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>ardav\u00edn Castro Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Perez gomariz rosa Mar\u00eda <\/li>\n<li>Jos\u00e9 ignacio Mayordomo camara (vocal)<\/li>\n<li>ignacio Javier Melero bermejo (vocal)<\/li>\n<li>Elena Fern\u00e1ndez ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ver\u00f3nica Parrillas Horche El trabajo de tesis doctoral, se basa en el an\u00e1lisis de las c\u00e9lulas dendr\u00edticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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