{"id":78810,"date":"2018-03-09T23:24:31","date_gmt":"2018-03-09T23:24:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/molecular-mechanisms-of-doe-action\/"},"modified":"2018-03-09T23:24:31","modified_gmt":"2018-03-09T23:24:31","slug":"molecular-mechanisms-of-doe-action","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/molecular-mechanisms-of-doe-action\/","title":{"rendered":"Molecular mechanisms of doe action"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Meritxell Orpinell Mercad\u00e9 <\/strong><\/h2>\n<p>El presente proyecto ha abordado la implicaci\u00f3n del gen dor (diabetes and obesity related gene) en la fisiopatolog\u00eda de la diabetes mellitus de tipo 2 mediante un an\u00e1lisis de la biolog\u00eda molecular (1) y celular (2) de la prote\u00edna codificada por \u00e9ste gen.     1,- an\u00e1lisis molecular del patr\u00f3n de distribuci\u00f3n y de la funci\u00f3n mediante la caracterizaci\u00f3n de interacciones con otras prote\u00ednas. En base a evidencias previas que sugieren un papel de dor como regulador de la actividad transcripcional, se ha establecido la potencial interacci\u00f3n de dor con prote\u00ednas implicadas en mecanismos de expresi\u00f3n g\u00e9nica, tales como receptores nucleares de hormona (tr, gr, ppar), coactivadores (src-1),histona acetilasas (cbp, p300), y desacetilasas (sirt1), mediante ensayos de inmunoprecipitaci\u00f3n de prote\u00edna o cromatina (chlp).     asimismo, se ha caracterizado de la interacci\u00f3n de dos prote\u00ednas citoplasm\u00e1ticas identificadas previamente por la t\u00e9cnica del doble h\u00edbrido en levadura. El an\u00e1lisis de la interacci\u00f3n de dor con translokina ha permitido establecer un posible mecanismo regulador de \u00e9sta en la translaci\u00f3n de dor al n\u00facleo y de sus niveles de expresi\u00f3n y, en consecuencia, de su actividad reguladora. Por otra parte, la interacci\u00f3n de dor con txnip ha permitido establecer una posible implicaci\u00f3n de dor en los mecanismos responsables del mantenimiento del potencial redox a nivel celular.     2,- la caracterizaci\u00f3n del patr\u00f3n de expresi\u00f3n celular y tisular de la prote\u00edna dor, tanto end\u00f3gena como ect\u00f3pica, ha permitido determinar mecanismos implicados en la localizaci\u00f3n y expresi\u00f3n de \u00e9sta, tales como la diferenciaci\u00f3n miog\u00e9nica, la actividad transcripcional, traduccional y proteasomal, la estabilidad del citoesqueto, el estado de fosforilaci\u00f3n, as\u00ed como el estado energ\u00e9tico o del potencial redox celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Molecular mechanisms of doe action<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Molecular mechanisms of doe action <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Meritxell Orpinell Mercad\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zorzano Olarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Vidal puig <\/li>\n<li>lLuis Fajas (vocal)<\/li>\n<li>Mar\u00eda \u00e1ngeles Mart\u00ednez balb\u00e1s (vocal)<\/li>\n<li>alex Vaquero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Meritxell Orpinell Mercad\u00e9 El presente proyecto ha abordado la implicaci\u00f3n del gen dor (diabetes and obesity related [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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