{"id":78826,"date":"2018-03-09T23:24:31","date_gmt":"2018-03-09T23:24:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-total-y-especiacion-de-selenio-en-materiales-biologicos-mediante-dilucion-isotopica\/"},"modified":"2018-03-09T23:24:31","modified_gmt":"2018-03-09T23:24:31","slug":"determinacion-total-y-especiacion-de-selenio-en-materiales-biologicos-mediante-dilucion-isotopica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/determinacion-total-y-especiacion-de-selenio-en-materiales-biologicos-mediante-dilucion-isotopica\/","title":{"rendered":"Determinaci\u00f3n total y especiaci\u00f3n de selenio en materiales biol\u00f3gicos mediante diluci\u00f3n isotopica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Hinojosa Reyes <\/strong><\/h2>\n<p>El selenio es un elemento esencial que juega un papel muy importante en la dieta humana. Sin embargo, la ingesta diaria \u00f3ptima se encuentra en un estrecho intervalo (50-200 ug.D\u00eda-1), fuera del cual se pueden presentar distintos desordenes cl\u00ednicos tanto a estados carenciales como de intoxicaci\u00f3n. algunos estudios sugieren que su deficiencia puede aumentar el riesgo de poder enfermedades coronarias y algunos tipos de c\u00e1ncer.  en este sentido, el consumo de diferentes suplementos de selenio, entre ellos las levaduras selenizadas, han incrementado notablemente. Sin embargo, la biodisponibilidad y toxicidad del elemento depende no s\u00f3lo de su concentraci\u00f3n total sino tambi\u00e9n de las formas f\u00edsico-qu\u00edmicas en que se encuentra, por tanto, el objetivo fundametnal de la presente tesis doctoral es la puesta apunto de nuevas metodolog\u00edas anal\u00edticas para la determinaci\u00f3n total y la expectaci\u00f3n de selenio en muestras biol\u00f3gicas de inter\u00e9s cl\u00ednico y nutricional mediante diluci\u00f3n isot\u00f3pica y espectrometr\u00eda de masas. As\u00ed, primeramente se puso a punto una metodolog\u00eda anal\u00edtica para la determinaci\u00f3n total de selenio en muestras biol\u00f3gicas mediante el an\u00e1lisis por diluci\u00f3n isot\u00f3pica en un icp-mc equipado con celda de colisi\u00f3n\/reaci\u00f3n. La metodolog\u00eda desarrollada se utiliz\u00f3 para estudiar los niveles de selenio en suero de personas sanas. posteriormente se puso apunto un m\u00e9todo anal\u00edtico para la especiaci\u00f3n cuantitativa de selenio en suero humano empleando la diluci\u00f3n isot\u00f3pica en su modalidad de adici\u00f3n post-columna, comparando dos tipos de separaci\u00f3n cromatogr\u00e1fica:  cromatograf\u00eda de intercambio ani\u00f3nico y cromatograf\u00eda de afinidad. La metodolog\u00eda desarrollada se utiliz\u00f3 para estudiar la distribuci\u00f3n de selenio entre la prote\u00edna s\u00e9ricas en personas sana y pacientes renales con el fin de detectar posibles diferencias entra ambas poblaciones. Por otro lado, se puso a unto un m\u00e9todo de an\u00e1lisis por diluci\u00f3n iso<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n total y especiaci\u00f3n de selenio en materiales biol\u00f3gicos mediante diluci\u00f3n isotopica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n total y especiaci\u00f3n de selenio en materiales biol\u00f3gicos mediante diluci\u00f3n isotopica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Hinojosa Reyes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Alonso Jos\u00e9 Ignacio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis G\u00f3mez ariza <\/li>\n<li>Fernando Moreno sanz (vocal)<\/li>\n<li>carmen Camara rico (vocal)<\/li>\n<li>maite Bueno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Hinojosa Reyes El selenio es un elemento esencial que juega un papel muy importante en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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