{"id":78837,"date":"2018-03-09T23:24:35","date_gmt":"2018-03-09T23:24:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-preferencias-conformacionales-de-analogos-de-fenilalanina\/"},"modified":"2018-03-09T23:24:35","modified_gmt":"2018-03-09T23:24:35","slug":"sintesis-y-preferencias-conformacionales-de-analogos-de-fenilalanina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estereoquimica-y-analisis-conformacional\/sintesis-y-preferencias-conformacionales-de-analogos-de-fenilalanina\/","title":{"rendered":"Sintesis y preferencias conformacionales de analogos de fenilalanina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Soledad Royo Gracia <\/strong><\/h2>\n<p>El trabajo realizado se enmarca dentro del dise\u00f1o de nuevos amino\u00e1cidos y el estudio de sus propiedades estructurales. En particular, se centra en el estudio de diferentes an\u00e1logos de fenilalanina, analizando de forma exhaustiva sus tendencias conformacionales. Poder disponer de diferentes derivados de fenilalanina cuyas preferencias conformacionales sean conocidas resulta muy interesante, dado que los residuos arom\u00e1ticos suelen desempe\u00f1ar un papel esencial en los procesos de reconocimiento molecular, siendo con frecuencia esenciales para que un p\u00e9ptido interaccione con su receptor biol\u00f3gico.  concretamente, se ha llevado a cabo la s\u00edntesis de cuatro derivados de fenilalanina en los cuales se ejerce un mayor o menor grado de control sobre la orientaci\u00f3n de su cadena lateral arom\u00e1tica. Los an\u00e1logos seleccionados son: difenilalanina (dip), alfa-metildifenilalanina [(alfame)dip], fluorenilglicina (flg) y el \u00e1cido 1-n-terc-butoxicarbonilamino-c-2,t-3-difenil-1-ciclopropancarbox\u00edlico (c3diphe). Todos ellos se han preparado tanto en forma rac\u00e9mica como en forma enantiom\u00e9ricamente pura, desarrollando para ello nuevas metodolog\u00edas sint\u00e9ticas o aplicando procedimientos ya descritos. En todos los casos, la resoluci\u00f3n de un  intermedio sint\u00e9tico mediante hplc sobre fases estacionarias quirales ha permitido el acceso al correspondiente amino\u00e1cido en forma enantiom\u00e9ricamente pura y adecuadamente protegido para su uso en s\u00edntesis pept\u00eddica. las preferencias conformacionales de estos an\u00e1logos de fenilalanina han sido determinadas mediante su incorporaci\u00f3n en peque\u00f1os p\u00e9ptidos modelo y el estudio estructural de los mismos se ha realizado tanto en disoluci\u00f3n como en estado s\u00f3lido a trav\u00e9s de t\u00e9cnicas como la resonancia magn\u00e9tica nuclear, la espectroscopia de infrarrojo y la difracci\u00f3n de rayos x sobre  monocristales. Estos estudios han permitido determinar el modo en que la modificaci\u00f3n introducida en cada derivado de fenilalanina afecta a sus pre<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y preferencias conformacionales de analogos de fenilalanina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y preferencias conformacionales de analogos de fenilalanina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Soledad Royo Gracia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/02\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Cativiela Mar\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Plumet ortega <\/li>\n<li>Miguel \u00e1ngel Miranda alonso (vocal)<\/li>\n<li>Manuel Rico sarompas (vocal)<\/li>\n<li>miriam Royo exp\u00f3sito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Soledad Royo Gracia El trabajo realizado se enmarca dentro del dise\u00f1o de nuevos amino\u00e1cidos y el estudio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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