{"id":78947,"date":"2006-03-03T00:00:00","date_gmt":"2006-03-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-cla%c2%adnicos-y-moleculares-para-el-diagnostico-y-tratamiento-de-la-evw-tipo-i\/"},"modified":"2006-03-03T00:00:00","modified_gmt":"2006-03-03T00:00:00","slug":"marcadores-cla%c2%adnicos-y-moleculares-para-el-diagnostico-y-tratamiento-de-la-evw-tipo-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-cla%c2%adnicos-y-moleculares-para-el-diagnostico-y-tratamiento-de-la-evw-tipo-i\/","title":{"rendered":"Marcadores cl\u00ednicos y moleculares para el diagn\u00f3stico y tratamiento de la evw tipo i"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  P\u00e9rez Rodr\u00edguez Mar\u00eda Almudena <\/strong><\/h2>\n<p>El factor von willebrand (fvw) es una glicoproteina multim\u00e9rica que media la adhesi\u00f3n del as plaquetas al subendotelio de los vasos da\u00f1ados; adem\u00e1s funciona como transportador del factor viii (fviii) en la circulaci\u00f3n. este factor es requerido para una hemostasia normal, mediando la formaci\u00f3n del trombo en los lugares de da\u00f1o vascular.  la enfermedad de von willebrand (evw) es un desorden hemorr\u00e1gico cong\u00e9nito causado por defectos gen\u00e9ticos en el gen del fvw. Se clasifica en los tipos 1, 2 y 3. A su vez, el tipo 2 se divide en cuatro subtipos: 2a, 2b, 2m y 2n. La preValencia de la enfermedad en la poblaci\u00f3n general es de un 1%. Su transmisi\u00f3n es autos\u00f3mica dominante o, menos frecuentemente, recesiva.  la evw tipo 1, caracterizada por una leve reducci\u00f3n del fvw estructuralmente normal, resulta bastante dificil de diagnosticar debido a la penetrancia incompleta, considerable variabilidad de niveles del fvw, la baja especificidad de s\u00edntomas de sangrado y baja sensibilidad de los test de diagn\u00f3stico. esto se complica todav\u00eda m\u00e1s, por el hecho de que la mayor\u00eda de los pacientes con evw tienen un ligero desorden con unos niveles de fvw en sangre muy pr\u00f3ximo al normal. Adem\u00e1s, se ha encontrado la existencia de una inconsistencia de ligamiento entre la evw tipo 1 y el locus del fvw. Con el fin de mejorar este diagn\u00f3stico de la evw tipo 1 y aprovechando la oportunidad que nos brind\u00f3 la uni\u00f3n europea (ue) de participar en un proyecto multic\u00e9ntrico europeo dedicado al estudio de la evw tipo 1 (mcmdm-1vwd) y centr\u00e1ndonos en las familias en el incluidas por nuestro centro, nos propusimos los siguientes objetivos: a) determinar el valor relativo de una serie de marcadores cl\u00ednicos y moleculares en el diagn\u00f3stico y tratamiento de la evw tipo 1 y su valor en el tratamiento. B) examinar la relaci\u00f3n entre haplotipos del gen del fvw y la cl\u00ednica y el diagn\u00f3stico de laboratorio en la evw tipo 1. C)determinar la proporci\u00f3n de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores cl\u00ednicos y moleculares para el diagn\u00f3stico y tratamiento de la evw tipo i<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores cl\u00ednicos y moleculares para el diagn\u00f3stico y tratamiento de la evw tipo i <\/li>\n<li><strong>Autor:<\/strong>\u00a0  P\u00e9rez Rodr\u00edguez Mar\u00eda Almudena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Batlle Fontrodona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Bello lopez Jos\u00e9 Luis <\/li>\n<li> Lopez fernandez Mar\u00eda  fernanda (vocal)<\/li>\n<li>Luis Javier Garc\u00eda frade (vocal)<\/li>\n<li>Ana Mar\u00eda Rodriguez torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de P\u00e9rez Rodr\u00edguez Mar\u00eda Almudena El factor von willebrand (fvw) es una glicoproteina multim\u00e9rica que media la adhesi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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