{"id":78958,"date":"2006-06-03T00:00:00","date_gmt":"2006-06-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patron-de-alteraciones-genetico-moleculares-en-los-carcinomas-epidermoides-de-laringe-y-faringe-y-en-sus-correspondientes-metastasis-linfaticas\/"},"modified":"2006-06-03T00:00:00","modified_gmt":"2006-06-03T00:00:00","slug":"patron-de-alteraciones-genetico-moleculares-en-los-carcinomas-epidermoides-de-laringe-y-faringe-y-en-sus-correspondientes-metastasis-linfaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/patron-de-alteraciones-genetico-moleculares-en-los-carcinomas-epidermoides-de-laringe-y-faringe-y-en-sus-correspondientes-metastasis-linfaticas\/","title":{"rendered":"Patron de alteraciones genetico moleculares en los carcinomas epidermoides de laringe y faringe y en sus correspondientes metastasis linfaticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Alonso Guervos <\/strong><\/h2>\n<p>Introducci\u00f3n: se han realizado importantes avances en el diagn\u00f3stico y tratamiento de los carcinomas faringolar\u00edngeos (cfl), aunque la supervivencia casi no se ha modificado en los \u00faltimos a\u00f1os, debido a que muchos se diagnostican en estadios avanzados. El consumo habitual de tabaco y alcohol es un factor de riesgo muy importante para este tipo de c\u00e1ncer. La principal causa de mortalidad en estos tumores son las recidivas locorregionales, la mayor\u00eda de ellas condicionadas por la presencia de met\u00e1stasis ganglionares. Los cfl presentan cambios cromos\u00f3micos y gen\u00e9ticos muy complejos y abundantes. se han dise\u00f1ado modelos de progresi\u00f3n tumoral caracterizados por el ac\u00famulo de alteraciones gen\u00e9tico-moleculares, pero no se han descrito los cambios espec\u00edficos que condicionan el desarrollo de las met\u00e1stasis.  objetivos: conocer los cambios cromos\u00f3micos y gen\u00e9ticos que conducen al cfl a desarrollar met\u00e1stasis ganglionares, determinando su papel en la progresi\u00f3n tumoral y en el pron\u00f3stico de la enfermedad.  metodolog\u00eda: se estudiaron muestras de tejido en fresco y  parafina en 56 cfl primarios y en 26 de sus correspondientes met\u00e1stasis ganglionares, por medio de cgh (\u00abcomparative genomic hybridization\u00bb) y mlpa (\u00abmultiplex ligation-dependent probe amplification\u00bb). Con cgh se detectaron alteraciones cromos\u00f3micas en todo el genoma y con mlpa se valoraron las alteraciones de 42 genes con importancia en el desarrollo de cfl. Todas las alteraciones cromos\u00f3micas y gen\u00e9ticas detectadas se correlacionaron con los datos cl\u00ednico-patol\u00f3gicos y citom\u00e9tricos de los pacientes.  resultados: los tumores primarios presentaron un alto n\u00famero de alteraciones cromos\u00f3micas, con m\u00e1s ganancias que p\u00e9rdidas, independientemente de la ploid\u00eda de la muestra. La amplificaci\u00f3n 11q13 fue la \u00fanica asociada a estadios avanzados (iii-iv) y presencia de met\u00e1stasis ganglionares, pero no se correlacion\u00f3 con la supervivencia. Las p\u00e9rdidas de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patron de alteraciones genetico moleculares en los carcinomas epidermoides de laringe y faringe y en sus correspondientes metastasis linfaticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patron de alteraciones genetico moleculares en los carcinomas epidermoides de laringe y faringe y en sus correspondientes metastasis linfaticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Alonso Guervos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Llorente Pendas Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>milagros Balbin felechosa (vocal)<\/li>\n<li>ignacio Cobeta marco (vocal)<\/li>\n<li>david alonso Hardisson hernaez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Alonso Guervos Introducci\u00f3n: se han realizado importantes avances en el diagn\u00f3stico y tratamiento de los carcinomas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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