{"id":78959,"date":"2006-06-03T00:00:00","date_gmt":"2006-06-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-la-dcr-cuantitativa-al-estudio-del-mieloma-multiple-estudios-de-enfermedad-residual-minima-y-expresion-genica\/"},"modified":"2006-06-03T00:00:00","modified_gmt":"2006-06-03T00:00:00","slug":"aplicacion-de-la-dcr-cuantitativa-al-estudio-del-mieloma-multiple-estudios-de-enfermedad-residual-minima-y-expresion-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/aplicacion-de-la-dcr-cuantitativa-al-estudio-del-mieloma-multiple-estudios-de-enfermedad-residual-minima-y-expresion-genica\/","title":{"rendered":"Aplicacion de la dcr. cuantitativa al estudio del mieloma multiple: estudios de enfermedad residual minima y expresion genica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Eugenia Alonso Sarasquete <\/strong><\/h2>\n<p>El mieloma m\u00faltiple (mm) es una enfermedad incurable en la que la mayor\u00eda de los pacientes recae por la persistencia de c\u00e9lulas tumorales que regeneran la enfermedad, concepto denominado enfermedad residual m\u00ednima (erm). El an\u00e1lisis de la erm ha demostrado su utilidad en la detecci\u00f3n precoz de reca\u00eddas en otras neoplasias hematol\u00f3gicas, por ello tratamos de estandarizar una t\u00e9cnica para su seguimiento. nuestro primer hallazgo se basa en el empleo de una nueva diana, el reordenamiento incompleto dj de los genes de inmunoglobulinas, para su amplificaci\u00f3n  mediante pcr cuantitativa para el estudio de erm. Esta diana tiene como principal ventaja estar presente hasta en el 60% de los pacientes con mm y adem\u00e1s no est\u00e1 mutada, lo que permite la correcta hibridaci\u00f3n de primers y sonda con la secuencia complementaria.  las t\u00e9cnicas est\u00e1ndar para seguimiento de erm son la citometr\u00eda de flujo (cmf) y la pcr cuantitativa en tiempo real (rq-pcr). Su aplicaci\u00f3n simult\u00e1nea en el an\u00e1lisis de erm de una serie de pacientes con mm en remisi\u00f3n completa (n=24) demostr\u00f3 que, a pesar de que la rq-pcr resulta ligeramente m\u00e1s sensible y detecta erm en mayor n\u00famero de casos (17\/24), la citometr\u00eda es m\u00e1s sencilla y aplicable a mayor n\u00famero de casos (90% cmf vs. 75% rq-pcr)  resultando la t\u00e9cnica de elecci\u00f3n para el seguimiento de erm en mm. Ambas t\u00e9cnicas coinciden en que una reducci\u00f3n de la carga tumoral por debajo de 0.01% confiere un mejor pronostico. el an\u00e1lisis de la expresi\u00f3n g\u00e9nica de la c\u00e9lula tumoral constituye un marcador propio y es uno de los principales determinantes de la biolog\u00eda de las c\u00e9lulas. Por ello analizamos los niveles de expresi\u00f3n de una serie de genes supresores tumorales (p14, p15 y p16) en pacientes con mm sintom\u00e1tico (n=52) y con mieloma quiescente (n=7) y encontramos una mayor expresi\u00f3n en los mm quiescentes respecto a los sintom\u00e1ticos. Considerando s\u00f3lo estos \u00faltimos, descubrimos una correlaci\u00f3n estad\u00edsticamente sign<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicacion de la dcr. cuantitativa al estudio del mieloma multiple: estudios de enfermedad residual minima y expresion genica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicacion de la dcr. cuantitativa al estudio del mieloma multiple: estudios de enfermedad residual minima y expresion genica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Eugenia Alonso Sarasquete <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcos Gonzalez Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas fernando San Miguel izquierdo <\/li>\n<li> De la rubia Javier (vocal)<\/li>\n<li>joaquin Martinez lopez (vocal)<\/li>\n<li> Ribera santasusana Jos\u00e9 M\u00aa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Eugenia Alonso Sarasquete El mieloma m\u00faltiple (mm) es una enfermedad incurable en la que la mayor\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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