{"id":78988,"date":"2006-09-03T00:00:00","date_gmt":"2006-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/generacion-y-caracterizacion-fenota%c2%adpica-del-raton-carente-en-cistationina-beta-sintasa-y-apolipoprotea%c2%adna-a-i\/"},"modified":"2006-09-03T00:00:00","modified_gmt":"2006-09-03T00:00:00","slug":"generacion-y-caracterizacion-fenota%c2%adpica-del-raton-carente-en-cistationina-beta-sintasa-y-apolipoprotea%c2%adna-a-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/generacion-y-caracterizacion-fenota%c2%adpica-del-raton-carente-en-cistationina-beta-sintasa-y-apolipoprotea%c2%adna-a-i\/","title":{"rendered":"Generaci\u00f3n y caracterizaci\u00f3n fenot\u00edpica del rat\u00f3n carente en cistationina beta sintasa y apolipoprote\u00edna a-i."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Carnicer Hijazo <\/strong><\/h2>\n<p>Elevados niveles de homociste\u00edna (hcy) y un descenso en el contenido de lipoprote\u00ednas de alta densidad (hdl) en plasma son situaciones consideradas como perjudiciales para la funci\u00f3n del endotelio vascular, adem\u00e1s, se ha demostrado que son factores de riesgo independiente en el desarrollo de las enfermedades cardiovasculares. en la presente investigaci\u00f3n se estudi\u00f3 el efecto de la combinaci\u00f3n de ambos factores a trav\u00e9s de la generaci\u00f3n de un modelo animal con deficiencia en la enzima cistationina beta sintasa y en la apolipoprote\u00edna a-i. Una vez que se hubo generado el rat\u00f3n doble deficiente y comprobado que manten\u00eda unos niveles elevados de homociste\u00edna (hiperhomocisteinemia) y un descenso en las lipoprote\u00ednas de alta densidad (hipoalfalipoproteinemia) se evaluaron las posibles alteraciones vasculares. El resultado m\u00e1s destacado fue que las deficiencias de manera independiente no ejerc\u00edan da\u00f1os severos sobre la funci\u00f3n endotelial, sin embargo, la interacci\u00f3n de ambas gener\u00f3 un aumento significativo de la tensi\u00f3n arterial. Esta hipertensi\u00f3n moderada se asoci\u00f3 a una disfunci\u00f3n en el metabolismo del \u00f3xido n\u00edtrico tal como indicaba el descenso en plasma de esta mol\u00e9cula y a un aumento de los niveles de la apolipoprote\u00edna a-iv; y era independiente tanto de la actividad arilesterasa de la enzima paraoxonasa, como del contenido lip\u00eddico transportado en las hdl.  se restablecieron los niveles de presi\u00f3n arterial hasta los niveles de presi\u00f3n mostrados por el grupo de ratones control gracias al tratamiento con simvastatina a lo largo de cuatro semanas. La simvastatina increment\u00f3 la disponibilidad de \u00f3xido n\u00edtrico tal y como suger\u00edan los niveles de esta mol\u00e9cula en plasma. Este efecto positivo no estaba asociado a un aumento del contenido de la \u00f3xido n\u00edtrico sintasa endotelial, sino que se vio favorecido gracias a la acci\u00f3n de la estatina sobre otras prote\u00ednas implicadas en la regulaci\u00f3n del \u00f3xido n\u00edtrico, al disminuir los niveles<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Generaci\u00f3n y caracterizaci\u00f3n fenot\u00edpica del rat\u00f3n carente en cistationina beta sintasa y apolipoprote\u00edna a-i.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Generaci\u00f3n y caracterizaci\u00f3n fenot\u00edpica del rat\u00f3n carente en cistationina beta sintasa y apolipoprote\u00edna a-i. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Carnicer Hijazo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas De La Osada Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Civeira murillo <\/li>\n<li>Francisco Blanco vaca (vocal)<\/li>\n<li>paloma Mart\u00edn sanz (vocal)<\/li>\n<li>Juan Sastre belloch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Carnicer Hijazo Elevados niveles de homociste\u00edna (hcy) y un descenso en el contenido de lipoprote\u00ednas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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