{"id":79020,"date":"2006-10-03T00:00:00","date_gmt":"2006-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-influencia-de-parametros-fa%c2%adsicos-en-la-construccion-de-modelos-de-calibracion-en-la-espectroscopia-en-el-infrarrojo-cercano\/"},"modified":"2006-10-03T00:00:00","modified_gmt":"2006-10-03T00:00:00","slug":"estudio-de-la-influencia-de-parametros-fa%c2%adsicos-en-la-construccion-de-modelos-de-calibracion-en-la-espectroscopia-en-el-infrarrojo-cercano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-influencia-de-parametros-fa%c2%adsicos-en-la-construccion-de-modelos-de-calibracion-en-la-espectroscopia-en-el-infrarrojo-cercano\/","title":{"rendered":"Estudio de la influencia de par\u00e1metros f\u00edsicos en la construcci\u00f3n de modelos de calibraci\u00f3n en la espectroscopia en el infrarrojo cercano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Damarih Valdes Calvino <\/strong><\/h2>\n<p>In the last years there has been an increase in the use of near infrared spectroscopy, due to its multiple advantages: it is a non-invasive and non-destructive technique, it requires very little or no sample preparation, the ability to provide measurements and results in a highly expeditious manner, the low cost of analysis, an absence of reagents; as well as the possibility of making simultaneous determination of physical and chemical parameters.  nonetheless, the characteristic of the nir signal requires the application of multivariate methods to obtain the desired information contained in the spectrum. The spectral variability produced by the insufficient control of physical parameters, gives rise to complex models of calibration as well as a poorer predictive capacity.  in an industrial process experimental conditions can not always be strictly controlled and variations of the physical conditions of the system (temperature, pressure, moisture, etc.) Often take place. The different arrangement from molecules in a crystalline structure gives rise to the polymorphism and this property complicate the models of calibration of samples in which this property is present.  in the pharmaceutical industry is very common that active principles can exist in two or more different crystalline forms (polymorphs). We have taken advantage of these differences for the characterization and determination of different polymorphs of a substance. One of the objectives of this thesis is to develop new methodologies of analysis for the identification and characterization of polymorphs of azithromycin by means of nir spectroscopy. models of calibration were developed based on the algorithm of partial least-square (pls) regression for the determination of a polymorphic form in the presence of another and were validated for their application in the pharmaceutical industry. In addition, a study of stability under high temperature and moisture conditions was car<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la influencia de par\u00e1metros f\u00edsicos en la construcci\u00f3n de modelos de calibraci\u00f3n en la espectroscopia en el infrarrojo cercano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la influencia de par\u00e1metros f\u00edsicos en la construcci\u00f3n de modelos de calibraci\u00f3n en la espectroscopia en el infrarrojo cercano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Damarih Valdes Calvino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcelo Blanco Romia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Silva rodriguez <\/li>\n<li>Manuel Hern\u00e1ndez c\u00f3rdoba (vocal)<\/li>\n<li>Santiago Maspoch andres (vocal)<\/li>\n<li>Luis fermin Capitan vallvey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Damarih Valdes Calvino In the last years there has been an increase in the use of near [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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