{"id":79021,"date":"2006-10-03T00:00:00","date_gmt":"2006-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistema-linamarasa-linamarina-mecanismos-y-progresoso-de-un-modelo-de-terapia-genica-combinada-contra-el-cancer\/"},"modified":"2006-10-03T00:00:00","modified_gmt":"2006-10-03T00:00:00","slug":"sistema-linamarasa-linamarina-mecanismos-y-progresoso-de-un-modelo-de-terapia-genica-combinada-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sistema-linamarasa-linamarina-mecanismos-y-progresoso-de-un-modelo-de-terapia-genica-combinada-contra-el-cancer\/","title":{"rendered":"Sistema linamarasa\/linamarina: mecanismos y progresoso de un modelo de terapia g\u00e9nica combinada contra el c\u00e1ncer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vega Garc\u00eda-escudero Barreras <\/strong><\/h2>\n<p>El sistema linamarasa\/linamarina (lis\/lin) se basa en la utilizaci\u00f3n del mecanismo natural de defensa anti-herv\u00edboros de la planta manihot esculenta crantz como estrategia asesino-suicida contra el c\u00e1ncer. Esta planta posee un gen, linamarasa (lis), que codifica una b-glucosidasa que hidroliza el sustrato in\u00f3cuo, linamarina (lin), produciendo acetona cianohidrina y glucosa. La acetona cianohidrina a ph superior a 6 y temperaturas mayores de 30\u00c2\u00bac se descompone espont\u00e1neamente en acetona y cianuro. Cuando la linamarina se expresa en c\u00e9lulas de mam\u00edfero, \u00e9sta es exportada al exterior celular donde se encuentra con la linamarina produciendo cianuro en el ambiente extracelular. El cianuro, adem\u00e1s, es capaz de atravesar libremente las membranas celulares, por lo que el sistema est\u00e1 asociado a un potente efecto colateral. El cianuro, como agente antitumoral, se une y bloquea la citocromo c oxidasa de la fosforilaci\u00f3n oxidativa, comprometiendo seriamente la funci\u00f3n respiratoria mitocondrial, ya que provoca la depleci\u00f3n de los niveles intracelulares de atp y promueve la generaci\u00f3n de especies reactivas de ox\u00edgeno debido al escape de electrones especialmente a trav\u00e9s de los complejos i y iii de la cadena transportadora de electrones. Ambos efectos conllevan a la fisi\u00f3n mitocondrial e inducen la muerte celular.  se han evaluado y comparado distintos vectores virales basados en retrovirus y adenovirus para el sistema lis\/lin, mostrando que los adenovirus defectivos de primera generaci\u00f3n derivados del adenovirus tipo 5 humano portadores del gen de la linamarasa (adenolis), son m\u00e1s eficientes que los retrovirus y permiten mayores niveles de expresi\u00f3n del transg\u00e9n. Adicionalmente, los adenolis demostraron ser los m\u00e1s adecuados para la realizaci\u00f3n de estudios in vivo, ya que permiten infectar un amplio espectro de c\u00e9lulas y explantes procedentes de glioblastomas de pacientes.  el efecto antitumoral del sistema lis\/lin se increme<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sistema linamarasa\/linamarina: mecanismos y progresoso de un modelo de terapia g\u00e9nica combinada contra el c\u00e1ncer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sistema linamarasa\/linamarina: mecanismos y progresoso de un modelo de terapia g\u00e9nica combinada contra el c\u00e1ncer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vega Garc\u00eda-escudero Barreras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Izquierdo Rojo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Luis Moreno mu\u00f1oz <\/li>\n<li>anna Ciafr\u00e9 silvia (vocal)<\/li>\n<li>Antonio Bru espino (vocal)<\/li>\n<li> De felipe fern\u00e1ndez pablo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vega Garc\u00eda-escudero Barreras El sistema linamarasa\/linamarina (lis\/lin) se basa en la utilizaci\u00f3n del mecanismo natural de defensa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,155,9,347,156],"tags":[169723,22851,169724,29532,30251,169722],"class_list":["post-79021","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia-clinica","category-patologia","tag-anna-ciafre-silvia","tag-antonio-bru-espino","tag-de-felipe-fernandez-pablo","tag-francisco-luis-moreno-munoz","tag-marta-izquierdo-rojo","tag-vega-garcia-escudero-barreras"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79021"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79021\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}