{"id":79060,"date":"2018-03-09T23:24:50","date_gmt":"2018-03-09T23:24:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-c-5-esterol-desaturasas-de-aspergilus-fumigatus-funcion-en-la-biosa%c2%adntesis-de-ergosterol-e-implicacion-en-la-sensibilidad-a-los-antifungicos\/"},"modified":"2018-03-09T23:24:50","modified_gmt":"2018-03-09T23:24:50","slug":"analisis-de-c-5-esterol-desaturasas-de-aspergilus-fumigatus-funcion-en-la-biosa%c2%adntesis-de-ergosterol-e-implicacion-en-la-sensibilidad-a-los-antifungicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-c-5-esterol-desaturasas-de-aspergilus-fumigatus-funcion-en-la-biosa%c2%adntesis-de-ergosterol-e-implicacion-en-la-sensibilidad-a-los-antifungicos\/","title":{"rendered":"An\u00e1lisis de c-5 esterol desaturasas de aspergilus fumigatus: funci\u00f3n en la bios\u00edntesis de ergosterol e implicaci\u00f3n en la sensibilidad a los antif\u00fangicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Alcazar Fuoli <\/strong><\/h2>\n<p>En el grupo de investigaci\u00f3n se han descrito dos genes de aspergillus fumigatus denominados cyp51a y cyp51b que codifican para la 14-alfa esterol demtilasa, enzima diana de los azoles. Mutaciones puntuales en algunas cepas de aspergillus fumigatus resistentes a los azoles ha sido descrita como la causante de su resistencia cruzada a azoles en esas cepas mutantes. Continuado con esa l\u00ednea de investigaci\u00f3n, en la b\u00fasqueda de mecanismos de resistencia a los antif\u00fangicos, se ha estudiado otros mecanismos de resistencia que pudieran explicar fenotipos de resistencia en cepas de a.Fumigatus no caracterizados. Un mecanismo bien definido, fundamentalmente en sacharomyeces cersisiae y c\u00e1ndida albicans, consiste en una disminuci\u00f3n, ausencia o deficiencia en la actividad del enzima c-5 esterol desaturasa. este enzima act\u00faa sobre la v\u00eda de s\u00edntesis del ergosterol y esta codificada por el gen erg3. En el trabajo presentado se ha realizado la identificaci\u00f3n y caracterizaci\u00f3n de tres genes de a.Fumigatus (erg3a, erg3b, y erg3c) que codifican posibles enzimas c-5 esterol desaturasas (erg3a, erg3b y erg3c). Se ha comprobado que los tres genes presentan una sola copia en el genoma de a.Fumigatus, y que los tres se expresan en condiciones normales de crecimiento. Se ha realizado un estudio funcional de las encimas c-5 esterol desaturasas de a.Fumigatus mediante la creaci\u00f3n de cepas de defectivas en los genes erg3a, erg3b y ergc. De tal forma que se ha estudiado la viabilidad de las cepas mutantes, su posible implicaci\u00f3n en la resistencia a los azoles y a la anfoterciina b y su implicaci\u00f3n en la bios\u00edntesis de ergosterol en a.Fumigatus.     por otro lado, la existencia en a.Fumigatus de dos enzimas cyp51 y tres enzimas c-5 esterol desaturasas llev\u00f3 a replantear la v\u00eda cl\u00e1sica de s\u00edntesis del ergoseterol descrita en s.Cervisiae. En este trabajo se describe por primera vez, la v\u00eda de s\u00edntesis del ergosterol en a.Fumigatus.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de c-5 esterol desaturasas de aspergilus fumigatus: funci\u00f3n en la bios\u00edntesis de ergosterol e implicaci\u00f3n en la sensibilidad a los antif\u00fangicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de c-5 esterol desaturasas de aspergilus fumigatus: funci\u00f3n en la bios\u00edntesis de ergosterol e implicaci\u00f3n en la sensibilidad a los antif\u00fangicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Alcazar Fuoli <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilia Mellado Terrado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>Luis Guerra romero (vocal)<\/li>\n<li>Alberto Alcazar golzalez (vocal)<\/li>\n<li>Manuel Segovia hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Alcazar Fuoli En el grupo de investigaci\u00f3n se han descrito dos genes de aspergillus fumigatus denominados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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