{"id":79096,"date":"2018-03-09T23:24:54","date_gmt":"2018-03-09T23:24:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-senal-de-calcio-regulacion-del-ph-y-liberacion-de-histamina-en-la-la%c2%adnea-celular-hmc-1\/"},"modified":"2018-03-09T23:24:54","modified_gmt":"2018-03-09T23:24:54","slug":"caracterizacion-de-la-senal-de-calcio-regulacion-del-ph-y-liberacion-de-histamina-en-la-la%c2%adnea-celular-hmc-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-los-farmacos\/caracterizacion-de-la-senal-de-calcio-regulacion-del-ph-y-liberacion-de-histamina-en-la-la%c2%adnea-celular-hmc-1\/","title":{"rendered":"Caracterizaci\u00f3n de la se\u00f1al de calcio, regulaci\u00f3n del ph, y liberaci\u00f3n de histamina en la l\u00ednea celular hmc-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Octavio Pernas Sueiras <\/strong><\/h2>\n<p>Los mastocitos tienen una importancia fundamental en procesos inflamatorios e inmunitarios del tipo de alergias, urticarias, as\u00ed como en enfermedades autoinmunes. Para su estudio, se han venido empleando habitualmente mastocitos de rata, mastocitos obtenidos mediante el cultivo de c\u00e9lulas precursoras hematopoy\u00e9ticas, as\u00ed como diversas l\u00edneas celulares. De entre estas \u00faltimas, la l\u00ednea hmc-1 es la mejor conocida y m\u00e1s ampliamente utilizadas, siendo su origen humano una gran ventaja a la hora de poder extrapolar los datos que se obtengan de su estudio al conocimiento de los mastocitos humanos. el objetivo de esta tesis es caracterizar el proceso de activaci\u00f3n de la l\u00ednea hmc-1, que es a\u00fan poco conocido. Para ello, se utiliza el par\u00e1metro de liberaci\u00f3n de histamina. Adem\u00e1s, se quiere estudiar la posible influencia sobre dicho proceso de dos importantes rutas metab\u00f3licas, que participan en la regulaci\u00f3n de numerosos procesos celulares:     * la se\u00f1al de calcio, un segundo mensajero universalmente reconocido.     * el ph intracelular, un par\u00e1metro f\u00edsico-qu\u00edmica que en estudios previos apunta un posible papel como nueva se\u00f1al de transducci\u00f3n.     las conclusiones de este trabajo son:     1,- una alcalinizaci\u00f3n intracelular es, por s\u00ed sola, una se\u00f1al suficiente para desencadenar la exocitosis en c\u00e9lulas hmc-1.     2,- en c\u00e9lulas hmc-1, un incremento de calcio citos\u00f3lico no es una se\u00f1al suficiente para inducir liberaci\u00f3n de histamina.     3,- las c\u00e9lulas hmc-1 presentan reservorios intracelulares de calcio modulables por diversos f\u00e1rmacos, cuyo vaciado induce una entrada de calcio a trav\u00e9s de canales soc.     4,- en c\u00e9lulas hmc-1, una alcalinizaci\u00f3n intracelular activa la salida de calcio a trav\u00e9s de la atpasa de calcio de la membrana plasm\u00e1tica.     5,- la estimulaci\u00f3n de la pkc incrementa la alcalinizaci\u00f3n intracelular y la liberaci\u00f3n de histamina inducidas por el cloruro am\u00f3nico en c\u00e9lulas hmc-1.     6,- en c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de la se\u00f1al de calcio, regulaci\u00f3n del ph, y liberaci\u00f3n de histamina en la l\u00ednea celular hmc-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de la se\u00f1al de calcio, regulaci\u00f3n del ph, y liberaci\u00f3n de histamina en la l\u00ednea celular hmc-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Octavio Pernas Sueiras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis M Botana L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: a. Casbiell Jes\u00fas <\/li>\n<li>Francisco Leira sanmartin (vocal)<\/li>\n<li>Manuel Freire garabal n\u00fa\u00f1ez (vocal)<\/li>\n<li>f\u00e9lix Vega lisi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Octavio Pernas Sueiras Los mastocitos tienen una importancia fundamental en procesos inflamatorios e inmunitarios del tipo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[6530,483,977],"tags":[169852,2701,107154,2447,89785,169851],"class_list":["post-79096","post","type-post","status-publish","format-standard","hentry","category-farmacologia-experimental","category-mecanismos-de-accion-de-los-farmacos","category-santiago-de-compostela","tag-a-casbiell-jesus","tag-felix-vega-lisi","tag-francisco-leira-sanmartin","tag-luis-m-botana-lopez","tag-manuel-freire-garabal-nunez","tag-octavio-pernas-sueiras"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79096"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79096\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}