{"id":79108,"date":"2018-03-09T23:24:54","date_gmt":"2018-03-09T23:24:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interes-clinico-de-las-concentraciones-intratumorales-de-acido-hialuronico-en-el-cancer-de-mama\/"},"modified":"2018-03-09T23:24:54","modified_gmt":"2018-03-09T23:24:54","slug":"interes-clinico-de-las-concentraciones-intratumorales-de-acido-hialuronico-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interes-clinico-de-las-concentraciones-intratumorales-de-acido-hialuronico-en-el-cancer-de-mama\/","title":{"rendered":"Interes clinico de las concentraciones intratumorales de acido hialuronico en el cancer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Corte Torres Mar\u00eda  Daniela <\/strong><\/h2>\n<p>Justificaci\u00f3n y objetivos: el \u00e1cido hialur\u00f3nico es un glicosaminoglicano de alto peso molecular localizado en la matriz tisular y fluidos biol\u00f3gicos de todos los vertebrados, en los cuales juega un papel fundamental regulando la migraci\u00f3n y diferenciaci\u00f3n celular. Estudios experimentales implicaron el \u00e1cido hialur\u00f3nico en la progresi\u00f3n de varios tipos de tumores como fribrosarcoma, c\u00e1ncer de pr\u00f3stata, c\u00e1ncer de mama, ovario, colon, estomago. En el presente estudio analizamos, mediante un m\u00e9todo de an\u00e1lisis inmunoradiom\u00e9trico, las concentraciones intratumorales de \u00e1cido hialur\u00f3nico  en el c\u00e1ncer de mama primario, su posible correlaci\u00f3n con caracter\u00edsticas cl\u00ednico-patol\u00f3gicas de las pacientes y de sus tumores, y su significaci\u00f3n pron\u00f3stica en una amplia serie de pacientes con c\u00e1ncer de mama.  m\u00e9todos: en el estudio se incluyeron 850 pacientes diagnosticadas de carcinoma invasivo de mama. El \u00e1cido hialur\u00f3nico fue determinado en las muestras tisulares mediante un m\u00e9todo inmunoradiom\u00e9trico. El contenido de receptores de estr\u00f3geno, progesterona, c-erbb-2, tpa, se determino mediante un enzima inmunoensayo especifico para cada uno de ellos, el egfr, ps2 y la catepsina d mediante ensayos inmunoradiom\u00e9tricos espec\u00edficos y finalmente el contenido de adn y porcentaje de c\u00e9lulas en fase s  por citometr\u00eda de flujo. El periodo medio de seguimiento fue de 55,1 meses.  resultados:  los niveles de \u00e1cido hialur\u00f3nico en los tumores mostraron una amplia variabilidad (4-59767 ng\/mg prote\u00edna; mediana: 4960), siendo significativamente superiores en pacientes j\u00f3venes (p=0,0001) y premenop\u00e1usicas (p=0.001) con respecto a las de mayor edad y posmenop\u00e1usicas, respectivamente. los niveles de ah fueron tambi\u00e9n significativamente mayores en los tumores ductales y lobulillares que en los otros tipos histol\u00f3gicos menos frecuentes (coloides, medulares o papilares) (p=0,0001). Existi\u00f3 una correlaci\u00f3n significativa y positiva e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interes clinico de las concentraciones intratumorales de acido hialuronico en el cancer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interes clinico de las concentraciones intratumorales de acido hialuronico en el cancer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Corte Torres Mar\u00eda  Daniela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Arguelles Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Vijande vazquez <\/li>\n<li>jaume Fern\u00e1ndez llamazares rodriguez (vocal)<\/li>\n<li>Mar\u00eda  del mar Abad hernandez (vocal)<\/li>\n<li>Mar\u00eda  aurora Astudillo gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Corte Torres Mar\u00eda Daniela Justificaci\u00f3n y objetivos: el \u00e1cido hialur\u00f3nico es un glicosaminoglicano de alto peso molecular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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