{"id":79110,"date":"2018-03-09T23:24:54","date_gmt":"2018-03-09T23:24:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-postoperatoria-de-la-respuesta-inflamatoria-sistemica-en-un-modelo-de-clampaje-aortico-suprarrenal-con-sin-shock-hemorragico\/"},"modified":"2018-03-09T23:24:54","modified_gmt":"2018-03-09T23:24:54","slug":"evolucion-postoperatoria-de-la-respuesta-inflamatoria-sistemica-en-un-modelo-de-clampaje-aortico-suprarrenal-con-sin-shock-hemorragico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/evolucion-postoperatoria-de-la-respuesta-inflamatoria-sistemica-en-un-modelo-de-clampaje-aortico-suprarrenal-con-sin-shock-hemorragico\/","title":{"rendered":"Evolucion postoperatoria de la respuesta inflamatoria sistemica en un modelo de clampaje aortico suprarrenal con\/sin shock hemorragico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Iglesias Iglesias <\/strong><\/h2>\n<p>Aims: la cirug\u00eda sobre la aorta abdominal induce una respuesta inflamatoria sist\u00e9mica (ris), origen de morbimortalidad postoperatoria. Objetivo: valorar la evoluci\u00f3n de la ris, en un modelo experimental que simula una cirug\u00eda electiva y otra de urgencia sobre la aorta abdominal (clampaje aortico suprarrenal sin\/con hemorragia previa). Material y m\u00e9todos: 15 minicerdos en 3 grupos. Instrumentalizaci\u00f3n: clampaje de la aorta suprarrenal por 30 m. Y by pass aorto-aortico con dacron. Grupos: 1) sham (solo disecci\u00f3n a\u00f3rtica); 2) clampaje; y 3) hemorragia del 40% y clampaje. Muestras: seis momentos (isquemia, reperfusi\u00f3n 15 m, 24, 48, 72 h y 7 d). Determinaciones: 1) citocinas pro y antiinflamatorias en suero: tnf- , il-1 , il-6, il-10, ifn- ; 2) mieloperoxidasa (mpo), ani\u00f3n superoxido (aso), superoxido-dismutasa (sdo) y malodialdehido (mda) en tejido renal; 3) nitritos en suero; 4) inos en tejido renal; 5) mol\u00e9culas de adhesi\u00f3n celular, solubles y en tejido renal (icam-1, vcam-1); y 6) nf b en ri\u00f1\u00f3n. Resultados: significativos incrementos de las citocinas proinflamatorias (tnf- , il-1 , ifn- ) y descensos de las antiinflamatorias (il-6 e il-10) desde el inicio del desclampaje, alcanzando su m\u00e1xima elevaci\u00f3n o descenso a las 72 h, tendiendo hacia la normalidad a los 7 d. Comportamiento similar de mpo, aso, sdo y mda a nivel renal, con m\u00e1ximas elevaciones entre las 48-72 h. Incremento en la producci\u00f3n de nitritos a partir de la reperfusi\u00f3n, alcanzando su pico a las 72 h (coincidiendo con una elevada expresi\u00f3n de inos), y disminuyendo sin alcanzar cifras basales a 7 d. Todas estas diferencias son significativamente mayores en el grupo con hemorragia (incluso durante la isquemia). En el grupo clampaje solo se detectaron mac en tejido renal a las 24 y 48 h.; Por el contrario en el grupo con hemorragia previa se detectaron todas las mac estudiadas, tanto solubles como tisulares; a los 7 d. Ninguna mac fue detectada, en ning\u00fan grupo. A las 48 h. De la revasc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evolucion postoperatoria de la respuesta inflamatoria sistemica en un modelo de clampaje aortico suprarrenal con\/sin shock hemorragico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evolucion postoperatoria de la respuesta inflamatoria sistemica en un modelo de clampaje aortico suprarrenal con\/sin shock hemorragico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Iglesias Iglesias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Lozano Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Ortega martin-corral <\/li>\n<li>Elena Balboa nelida (vocal)<\/li>\n<li>Javier Arias diez (vocal)<\/li>\n<li> Gutierrez Juli\u00e1n Jos\u00e9 M\u00aa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Iglesias Iglesias Aims: la cirug\u00eda sobre la aorta abdominal induce una respuesta inflamatoria sist\u00e9mica (ris), origen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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