{"id":79117,"date":"2018-03-09T23:24:54","date_gmt":"2018-03-09T23:24:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/morphological-anda-molecular-studies-of-cell-death-induced-buy-h1-histamine-antagonists-in-human-tumour-cells\/"},"modified":"2018-03-09T23:24:54","modified_gmt":"2018-03-09T23:24:54","slug":"morphological-anda-molecular-studies-of-cell-death-induced-buy-h1-histamine-antagonists-in-human-tumour-cells","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/morphological-anda-molecular-studies-of-cell-death-induced-buy-h1-histamine-antagonists-in-human-tumour-cells\/","title":{"rendered":"Morphological anda molecular studies of cell death induced buy h1 histamine antagonists in human tumour cells"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sh. Muhialdin Jangi <\/strong><\/h2>\n<p>Se ha descrito que la histamina es una amina biog\u00e9nica que interviene en la proliferaci\u00f3n de diferentes c\u00e9lulas normales y tumorales. Sin embargo, en algunos c\u00e1nceres humanos, como en la leucemia aguda de c\u00e9lulas t (all) y en el melanoma cut\u00e1neo, su efecto todav\u00eda no ha sido aclarado. En el presente trabajo hemos estudiado el efecto de la histamina y de sus antagonistas en l\u00edneas celulares de all, denominadas cem y jurkat; y en l\u00edneas celulares de melanoma denominadas a375, hs294t, ht144 y mjoi. Hemos observado que el tratamiento in vitro con histamina no ejerce ning\u00fan efecto sobre las c\u00e9lulas leuc\u00edmicas, pero incrementa la proliferaci\u00f3n de las c\u00e9lulas de melanoma humano. Adem\u00e1s, la histamina end\u00f3gena act\u00faa como un factor de supervivencia y estimulador de la proliferaci\u00f3n celular, tanto en las c\u00e9lulas leuc\u00e9micas como en las de melanoma ya que todos los antagonistas del receptor h1 de la histamina utilizados, dihphenidrmina, terfenadina y astemizol inhibieron la proliferaci\u00f3n celular e indujeron muerte celular por apoptosis de forma muy significativa. Sin embargo, la viabilidad tras el tratamiento de c\u00e9lulas normales como linfocitos obtenidos de sangre perif\u00e9rica, melanocitos y fibroblastos embrionarios, no se modific\u00f3.     para caracterizar el tiempo de muerte celular inducido por los antihistam\u00ednicos en las c\u00e9lulas tumorales, analizamos los cambios morfol\u00f3gicos y bioqu\u00edmicos inducidos en las c\u00e9lulas en respuesta a estos compuestos. Los estudios morfol\u00f3gicos, realizados mediante microscopia de luz, de fluorescencia y electr\u00f3nica de transmisi\u00f3n, han puesto de manifiesto en las c\u00e9lulas tratadas todos los procesos celulares de apoptosis, como condensaci\u00f3n celular, condensaci\u00f3n de la cromatina y fragmentaci\u00f3n nuclear. Tambi\u00e9n hemos detectado los cambios bioqu\u00edmicos de apoptosis, como la externalizaci\u00f3n de la fosfatidlserina en la membrana plasm\u00e1tica, fragmentaci\u00f3n del dna, colapso de la membrana mitocondrial, liberaci\u00f3n del ci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Morphological anda molecular studies of cell death induced buy h1 histamine antagonists in human tumour cells<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Morphological anda molecular studies of cell death induced buy h1 histamine antagonists in human tumour cells <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sh. Muhialdin Jangi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Boyano L\u00f3pez Mar\u00eda Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Diaz perez <\/li>\n<li>salvador Francisco Ali\u00f1o pellicer (vocal)<\/li>\n<li>boris Zhivotovisky (vocal)<\/li>\n<li>melchor Alvarez de mon soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sh. Muhialdin Jangi Se ha descrito que la histamina es una amina biog\u00e9nica que interviene en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1989,347,12909],"tags":[169894,169893,9396,14431,26970,169892],"class_list":["post-79117","post","type-post","status-publish","format-standard","hentry","category-cultivo-de-tejidos","category-oncologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-boris-zhivotovisky","tag-boyano-lopez-maria-dolores","tag-jose-luis-diaz-perez","tag-melchor-alvarez-de-mon-soto","tag-salvador-francisco-alino-pellicer","tag-sh-muhialdin-jangi"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79117"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79117\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}